Natural antibodies could combat Tasmanian devil cancer

May 5, 2016 by Rebecca Tucker, Deakin University
Credit: Save the Tasmanian Devil Program

Deakin University scientists may have found a way to stop the cancer that has been killing Tasmanian devils for the past 20 years.

And the devils (Sarcophilus harrisii) could actually already hold the solution – natural antibodies found in the marsupial's immune system.

Dr Beata Ujvari, from Deakin's Centre for Integrative Ecology within the School of Life and Environmental Sciences, investigated differences in molecules found in the devils' immune systems, comparing those that had the , known as the Tasmanian Devil Facial Tumour Disease, and those that didn't.

We know from human and animal studies that certain natural antibodies are able to recognise and kill cancerous cells, so we wanted to see whether the presence of these molecules would also determine tumour development in Tasmanian devils," Dr Ujvari said.

"We found that devils that have a higher ratio of these natural antibodies were less likely to have cancer.

"We can deduce then that devils with higher natural antibody ratio are therefore less susceptible to the contagious cancer."

Dr Ujvari said the results could potentially halt the spread of disease that has devastated the Tasmanian devil population since its first sighting in 1996, hopefully enabling new vaccine and treatment options.

The research, "Immunoglubolin dynamics and cancer prevalence in Tasmanian devils (Sarcophilus harrisii)" is published in the latest edition of Nature Scientific Reports.

"Anti-tumour vaccines that enhance the production of these natural antibodies, or direct treatment of the cancer with , could become a solution to help halt this disease," Dr Ujvari said.

"This process known as 'active immunotherapy', is becoming more and more accepted in treating human cancers, and we think it could be the magic bullet in saving the Tasmanian devils from extinction."

The facial cancer is spread from devil to devil via biting during social interactions, and has caused massive population declines of Tasmanian devils since its first sighting in 1996, in Tasmania.

Dr Ujvari said that because the cancer was transmitted from devil to devil, their should recognise the cells as foreign objects, like a pathogen, and work to eliminate them from the victim's system.

"However, this disease's cells are able to avoid recognition by the devils' immune systems and develop into large ulcerating tumours that ultimately kills the animals," she said

In 2009, the Australian Government listed the Tasmanian devil as Endangered under national environmental law. It is also listed as Endangered under the Tasmania's Threatened Species Protection Act 1995.

The Tasmanian devil has also been listed as Endangered on the Red List of the International Union for the Conservation of Nature and Natural Resources.

Explore further: Second contagious form of cancer found in Tasmanian devils

More information: Beata Ujvari et al. Immunoglubolin dynamics and cancer prevalence in Tasmanian devils (Sarcophilus harrisii), Scientific Reports (2016). DOI: 10.1038/srep25093

Related Stories

Second contagious form of cancer found in Tasmanian devils

December 28, 2015

Transmissible cancers—cancers which can spread between individuals by the transfer of living cancer cells—are believed to arise extremely rarely in nature. One of the few known transmissible cancers causes facial tumours ...

Ancient genes may explain modern threat to Tasmanian devils

December 5, 2012

(Phys.org)—Tasmanian devils had low immune gene diversity for hundreds, and possibly thousands, of years before the emergence of Devil Facial Tumour Disease, researchers at the University of Sydney and University of Adelaide ...

Recommended for you

Team uncovers the underlying mechanisms of 3-D tissue formation

November 21, 2018

If you want to build an organ for transplant, you need to think in 3-D. Using stem cells, scientists are now able to grow parts of organs in the lab, but that is a far cry from constructing a fully-formed, functioning, three-dimensional ...

What makes vertebrates special? We can learn from lancelets

November 21, 2018

Scientists once thought that humans must have 2 million genes to account for all our complexity. But since sequencing the human genome, researchers have learned that humans only have about 19,000 to 25,000 genes—not many ...

Scientists help identify key hantavirus receptor

November 21, 2018

A global team of investigators has identified a key protein involved in Hantavirus Pulmonary Syndrome (HPS), a serious and sometimes fatal respiratory disease, according to research published today in the journal Nature.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.