Scientists discover an early modern human with a recent neanderthal ancestor

July 27, 2015, Institute of Vertebrate Paleontology and Paleoanthropology
Fig.1 Oase 1, an early modern human mandible from the Peştera cu Oase of Romania. Credit: FU Qiaomei

Neanderthals are thought to have disappeared in Europe approximately 39,000–41,000 years ago but they have contributed 1–3% of the DNA of present-day people in Eurasia. Surprisingly, analyses of present-day genomes have not yielded any evidence that Neanderthals mixed with modern humans in Europe, despite the fact that Neanderthals were numerous there and cultural interactions between the two groups have been proposed. Dr. FU Qiaomei, Institute of Vertebrate Paleontology and Paleoanthropology of Chinese Academy of Sciences (IVPP), and scientists from Germany, USA, Romania and Canada, discovered that a 37,000–42,000-year-old modern human from Peştera cu Oase, Romania had the order of 6–9% of the genome derived from Neanderthals, more than any other modern human sequenced to date.

The finding published online June 22 in Nature suggests that the mixture between modern humans and Neanderthals was not limited to the first ancestors of present-day people to leave Africa, or to people in the Near East, and it occurred later as well and probably in Europe.

Oase 1, a modern human mandible, was found in 2002 in the Peştera cu Oase, Romania. The age of this specimen has been estimated to be,37,000–42,000 years by direct radiocarbon dating. Oase 1 is therefore one of the earliest modern humans in Europe. Its morphology is generally modern but some aspects are consistent with Neanderthal ancestry.

Researchers prepared two DNA extracts from 25 mg and 10 mg of bone powder removed from the inferior right ramus of Oase 1. Although the specimen contains small amounts of human DNA, they used an enrichment strategy to isolate sites that are informative about its relationship to Neanderthals and present-day humans, and discovered that on the order of 6–9% of the genome of the Oase individual is derived from Neanderthals, more than any other modern human sequenced to date. Three chromosomal segments of Neanderthal ancestry are over 50 centimorgans in size, indicating that this individual had a Neanderthal ancestor as recently as four to six generations back. "However, the Oase individual does not share more alleles with later Europeans than with East Asians, suggesting that the Oase population did not contribute substantially to later humans in Europe", said FU Qiaomei, lead author of the study.

Fig.2 The Peştera cu Oase of Romania, where Oase 1, one of the earliest modern humans in Europe unearthed in 2002. Credit: FU Qiaomei
"The fact that the Oase 1 individual had a Neanderthal ancestor removed by only four to six generations allows this Neanderthal admixture to be dated to less than 200 years before the time he lived. However, the absence of a clear relationship of the Oase 1 individual to later in Europe suggests that he may have been a member of an initial early modern human population that interbred with Neanderthals but did not contribute much to later European populations. To better understand the interactions between early modern and Neanderthal populations, it will be important to study other specimens that, like Oase 1, have been suggested to carry morphological traits suggestive of admixture with Neanderthals", said lead author Dr. Mateja Hajdinjak, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology.

Explore further: Genetic analysis of 40,000-year-old jawbone reveals early modern humans interbred with Neandertals

More information: "An early modern human from Romania with a recent Neanderthal ancestor." Nature (2015) DOI: 10.1038/nature14558

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1 / 5 (3) Jul 28, 2015
RNA-mediated events link gene duplication and fixation of nutrient-dependent amino acid substitutions to chromosomal rearrangements and biodiversity in all vertebrates via the conserved molecular mechanisms of biophysically constrained protein folding chemistry that links a single amino acid substitution to differences between the cell types of gorillas compared to chimpanzees and humans.

"For example, the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla" (p. 127). -- http://www.jstor..../4444260

Reporting links between ecological variation and virus-driven nutrient-dependent ecological adaptations as if different primate species "evolved" or "mixed" exemplifies pseudoscientific nonsense.

~10% of the human genome still varies among different populations/individuals because the variations are nutrient-dependent and pheromone-controlled.
1 / 5 (3) Jul 28, 2015

See also: "The method appears particularly promising in archaeology, where it can reveal the diets and lifestyles of past cultures. Still, the technique has a long way to go before it reaches the maturity of paleogenetics, chiefly because methods to sequence amino acids lag behind DNA sequencing."

Claims about biodiversity that do not include experimental evidence of how the diversity arose in the context of biophysically constrained protein folding chemistry will never be taken seriously now that Koonin has stated: "The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis..."

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