A team of chemists at Nagoya University has synthesized novel transition metal-complexed cycloparaphenylenes (CPPs) that enable selective monofunctionalization of CPPs for the first time, opening doors to the construction of unprecedented nanocarbons.
Nagoya, Japan - Professor Kenichiro Itami, Yasutomo Segawa and Natsumi Kubota of the JST-ERATO Itami Molecular Nanocarbon Project and the Institute of Transformative Bio-Molecules (ITbM), Nagoya University have synthesized novel cycloparaphenylene (CPP) chromium complexes and demonstrated their utility in obtaining monofunctionalized CPPs, which could become useful precursors for making carbon nanotubes with unprecedented structures. CPPs consist of a chain of benzene rings and are the shortest segment of carbon nanotubes. Since their first synthesis and isolation in 2008, CPPs have attracted wide attention in the fields of materials science and supramolecular chemistry. Applying the basic concepts of chromium arene chemistry, Itami and his coworkers have performed the first selective installation of a functional group on CPP, which has previously been difficult due to multiple reactive arene sites on the CPP ring. By being able to selectively install and tune the functional groups on CPPs, it is envisaged that carbon nanotubes with new properties can be constructed by this method.
The study, published online on January 12, 2015 in the Journal of the American Chemical Society, illustrates the first synthesis, isolation and analysis of a CPP chromium complex, which enables a one-pot access to monofunctionalized CPPs. This outcome is believed to be a significant advance in the fields of both CPP chemistry and organometallic chemistry.
Arenes are known to coordinate to transition metals and the corresponding metal complexes exhibit different reactivities relative to the free arene. CPPs, which consist of a chain of arenes, also reacted with chromium carbonyl to successfully generate the first chromium complex of CPP. Interestingly, the main product was a CPP with one chromium moiety complexed to one arene on the outer side of the ring, as confirmed by 1H NMR (nuclear magnetic resonance) spectroscopy, high-resolution mass spectrometry and X-ray crystallography.
"Chromium arene chemistry is a well-established area and we decided to apply this organometallic method to synthesize the first CPP chromium complex," says Itami, the Director of the JST-ERATO project and the Institute of Transformative Bio-Molecules. "As CPPs have a number of arene rings, we initially expected that chromium would form a complex with each arene ring," says Segawa, a group leader of the JST-ERATO project. "However, we were surprised to see that CPP reacted with chromium in a 1:1 ratio in all the conditions that we tried. Simulation of the molecular structure suggested that the first equivalent of chromium complexed to CPP lowers its reactivity, thus preventing the reaction with a second chromium moiety."
Upon finding that a monometallic CPP complex could be obtained, Itami's team explored the possibility of obtaining monofunctionalized CPPs from this complex. Itami and Segawa describe the steps in achieving this. "This was not an easy task as chromium arene complexes are usually air and light sensitive, and CPP chromium complexes were no exception. But Natsumi worked persistently to obtain a pure crystal of the first CPP chromium complex," says Itami. "We then performed the subsequent reactions in one-pot, to synthesize monofunctionalized CPPs after addition of base/electrophiles and removal of the metal from the CPP chromium complex," says Segawa.
Selective monofunctionalizations of CPPs i.e. installation of one functional group at a single position on the arene ring, are difficult to achieve as all carbon-hydrogen bonds on the arene rings are chemically equivalent. Direct functionalization of metal-free CPPs usually leads to multiple substitutions on the arene rings in an uncontrolled manner. Despite CPPs being desirable components for carbon nanotubes, there has been no efficient method to obtain directly functionalized CPPs up to now.
"We were pleased to see that a functional group could be selectively installed on one arene ring via chromium coordination of CPPs," says Segawa. "As electrophiles, we utilized silyl, boryl and ester groups, which act as handles that can be easily transformed to other useful functionalities," he continues. Itami says, "We hope that this new approach evolves to become a valuable method to construct carbon nanotubes with unique structures and properties."
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This article "η6-Cycloparaphenylene Transition Metal Complexes: Synthesis, Structure, Photophysical Properties, and Application to the Selective Monofunctionalization of Cycloparaphenylenes" by Natsumi Kubota, Yasutomo Segawa, and Kenichiro Itami is published online on January 12, 2015 in the Journal of the American Chemical Society. DOI: 10.1021/ja512271p