Tissues tell the tale: Non-invasive optical technique detects cancer by looking under the skin

September 24, 2012
Image (a) on the left shows a healthy network of blood vessels in the lower layer of skin on the hand palm. Image (b) shows blood vessels supplying a basal cell carcinoma on the forehead. The effects of disease on the vascular are evidenced by the branching pattern of vessels in image (b), with abnormally large vessels for a depth range similar to image (a). Both images show a 2x2 millimeter area. Credit: Medical University Vienna/ Biomedical Optics Express

The trained eye of a dermatologist can identify many types of skin lesions, but human sight only goes so far. Now an international team of researchers has developed an advanced optics system to noninvasively map out the network of tiny blood vessels beneath the outer layer of patients' skin, potentially revealing telltale signs of disease. Such high resolution 3-D images could one day help doctors better diagnose, monitor, and treat skin cancer and other skin conditions. The research was published today in the Optical Society's open-access journal Biomedical Optics Express.

Researchers from Medical University Vienna (MUW) in Austria and the Ludwig-Maximilians University in Munich, Germany, used a technique called optical (OCT) to "see" beneath the surface of skin. The researchers tested their system on a range of different skin conditions, including a healthy human palm, allergy-induced eczema on the forearm, dermatitis on the forehead, and two cases of – the most common type of skin cancer – on the face. Compared to healthy skin, the network of vessels supplying blood to the tested lesions showed significantly altered patterns. "The condition of the vascular network carries important information on tissue health and its nutrition," says Rainer Leitgeb, a researcher at MUW and the study's principal investigator. "Currently, the value of this information is not utilized to its full extent."

Ophthalmologists have used OCT since the 1990s to image different parts of the eye and the technology has recently attracted increased interest from dermatologists. OCT has many advantages over other imaging techniques: It is non-invasive and provides high-resolution images at high speed. OCT is typically used to show tissue structure, but it can also reveal the pattern of , which carry important clues about disease, by capitalizing on the unique optical properties of flowing .

This is a 2x2x2mm extracted blood vessel structure of basal cell carcinoma in vivo exhibiting a chaotic vascular pattern (left). Virtually cut volume obtained with OCT displaying the embedded blood vessels in red (right). Credit: Medical University Vienna

The researchers at MUW are the first to use OCT to visualize the network of blood vessels in human skin that feed cancerous skin lesions. To maximize the quality of the images the team employed a high-tech laser light source developed by collaborators from the Ludwig-Maximilians University. The laser enabled unprecedented high-speed imaging and operated at a near-infrared wavelength that gave better penetration into skin tissue.

"High speed is of paramount importance in order to image lesions in vivo and in situ while minimizing the effect of involuntary patient motion," explains researcher Cedric Blatter of MUW. The device also shapes the light in a special way forming a Bessel beam, which can reform, or heal, its shape even if portions of it are blocked. The beam enabled the researchers to keep the images in focus across a depth range of approximately 1 millimeter.

This is a 2x2x2mm extracted blood vessel structure in 3-D of healthy skin in vivo obtained with the label-free optical motion contrast method (left). Virtually cut volume obtained with OCT displaying the embedded blood vessels in red (right). Credit: Optics Express (2011)

The team's images of basal cell carcinoma showed a dense network of unorganized blood vessels, with large vessels abnormally close to the surface. The larger vessels branch into secondary vessels that supply blood to energy-hungry tumor regions. The images, together with information about blood flow rates and tissue structure, could yield important insights into the metabolic demands of tumors during different growth stages.

The imaging system shows the most promise for clinical application in the diagnosis and treatment of , the researchers believe. "We hope that improved in-depth diagnosis of tissue alterations due to disease might help to reduce the number of biopsies by providing better guidance," says Leitgeb. The system could also be used by doctors to assess how quickly a tumor is likely to grow and spread, as well as to monitor the effectiveness of treatments such as topical chemotherapy. "Treatment monitoring may also be expanded toward inflammatory and auto-immune related dermatological conditions," Blatter notes.

Going forward, the researchers would like to increase the field of view of the device so that they can image the full lesion along with its border to healthy tissue. They are also working on speeding up the post-processing of the optical signal to enable live vasculature display, and improving the portability of the system, which currently occupies an area about half the size of an office desk. "We believe that in the future our method will help to simplify non-invasive dermatological in vivo diagnostics and allow for in-depth treatment monitoring," says Blatter.

Explore further: Catching cancer's spread by watching hemoglobin

More information: "In-situ Structural and Microangiographic Assessment of Human Skin Lesions with High-speed OCT (www.opticsinfobase.org/boe/abs … fm?uri=boe-3-10-2636)," Biomedical Optics Express, Vol. 3, Issue 10, pp. 2636-2646 (2012).

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not rated yet Sep 24, 2012
All the technology in the world doesn't help unless doctors and nurses run the right tests to realize you have or may have a cancer.

A guy down the street from me just found out he has metastasized cancer throughout his entire lymph system, gall bladder, a kidney, and colon, and had the colon removed, and lymph nodes removed, and is pissing in a bag too as well, all because it was never symptomatic nor diagnosed till the last possible moment when he pissed blood one day.

To me, it seems like it probably started in the lymph nodes and went everywhere else. Poor guy didn't know what was happening till it hit all his organs at once.

I have no idea what his life expectancy is at this point, but it probably isn't very high.

Next time your have pesistent symptoms of any kind, and/or you doctor gives you a diagnosis which seems inconsistent or insufficient, get a second and third opinion. I should take my own advise.

These technologies can't help you much if nobody ever does the test...

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