Paper describes new method to understand sources of noise in gene-expression

(Phys.org)—Abhyudai Singh, assistant professor of electrical and computer engineering at the University of Delaware, describes a new method to understand sources of "noise" in gene-expression that create variability in protein levels in a paper published in Molecular Systems Biology, a publication of Nature, on Aug. 28. 

This noise is expressed as variability in the levels of proteins/mRNAs in a cell.

Understanding which biochemical processes contribute to this variability is an important problem, since protein variability plays important roles such as driving genetically identical cells to different cell fates and buffering from unpredictable and hostile changes in their environment.

The paper, entitled "Dynamics of Protein Noise Can Distinguish Between Alternate Sources of Gene-Expression Variability" develops a new method that uses changes in protein levels inside single cells to pinpoint the primary source of gene-expression noise. 

In collaboration with Prof. Leor Weinberger's group at the Gladstone Institute of Virology and Immunology, San Francisco, Singh applied this method to the (HIV) system, where gene-expression noise can drive the into latency, a dormant drug-resistant state.

The results revealed that random bursts of mRNA production drive variability in the levels of key viral during human cell infection.

"We believe that understanding the source of viral gene-expression noise will have important implications in designing therapies for preventing HIV entering latency," Singh said.


Explore further

Researchers identify the source of 'noise' in HIV

More information: www.nature.com/msb/journal/v8/ … /full/msb201238.html
Journal information: Molecular Systems Biology , Nature

Citation: Paper describes new method to understand sources of noise in gene-expression (2012, September 26) retrieved 18 October 2019 from https://phys.org/news/2012-09-paper-method-sources-noise-gene-expression.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
0 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more