A faster, simpler test for disease biomarkers

December 17, 2007

In an advance toward earlier diagnosis of cancer and other disorders, scientists are reporting development of a potentially fast, simple and inexpensive blood test to detect disease “biomarkers.” The study is scheduled for the Dec. 26 issue of ACS’ Journal of the American Chemical Society.

Cagri A. Savran and colleagues explain that serum biomarkers can reveal critical information about the onset and progression of many diseases. Several roadblocks hinder clinical use of existing biomarker tests, which will demand smaller sensors, faster detection times, and less expensive ways of analyzing samples of blood and other body fluids.

The study describes development of an integrated serum biomarker detection system for the folate receptor and testing of blood samples from patients with different types of cancer. Researchers captured the folate receptors — proteins that are biomarkers for the growth of cancer cells — with microscopic magnetic beads and assembled them to form a structure termed a “diffraction grating.” A laser beam focused on the grating yielded a pattern that could potentially be used to determine the biomarker concentration and thus the state of tumor growth.

“The same principles presented here should apply for detection of many other disease markers present in various body fluids,” the researchers stated. “Due to its simplicity and high sensitivity, we expect this method to be extremely useful both in research laboratories and in development of devices for point-of-care diagnostics.”

Source: ACS

Explore further: Early blood signatures of vaccine immunogenicity

Related Stories

Early blood signatures of vaccine immunogenicity

April 26, 2017

Within seven days of vaccination, a blood test early after vaccination can predict whether vaccines based on living, modified viruses have had the desired effect. This is one of the results of a new study from a large European ...

Blood samples give clues to social inequality

April 24, 2017

More than a decade's worth of blood samples in Portugal and Ireland are being analysed to look for clues about the health impacts of socio-economic inequalities on children.

New blood test may better predict gestational diabetes

April 27, 2017

A new study led by researchers at Brigham and Women's Hospital has found that a single measurement of plasma glycated CD59 (GCD59), a novel biomarker for diabetes, at weeks 24-28 of gestation identified, with high sensitivity ...

New method for early screening of colorectal cancer

April 26, 2017

A highly sensitive method that can detect even the earlier stages of colorectal cancer has been developed by researchers in Japan. Shimadzu Corporation, the Kobe University Graduate School of Medicine, and the National Cancer ...

Recommended for you

Hubble's bright shining lizard star

April 28, 2017

In space, being outshone is an occupational hazard. This NASA/ESA Hubble Space Telescope image captures a galaxy named NGC 7250. Despite being remarkable in its own right—it has bright bursts of star formation and recorded ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.