Flipping the 'off' switch on cell growth

A protein known for turning on genes to help cells survive low-oxygen conditions also slows down the copying of new DNA strands, thus shutting down the growth of new cells, Johns Hopkins researchers report. Their discovery ...

Stem cells: Tuning the death sentence

In this week's issue of Science Signaling (22 January, 2013), Danen and colleagues of the Division of Toxicology of LACDR report novel insights into the question how stem cells decide to commit suicide when their DNA is damaged.

Functional genomics gets tiny

A little more than a decade ago, researchers discovered an ancient mechanism that cells use to silence genes. Like a dimmer switch turning down a light, RNA interference (RNAi) dials down gene activity in simple organisms ...

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