Nucleic Acids Research (NAR) publishes the results of leading edge research into physical, chemical, biochemical and biological aspects of nucleic acids and proteins involved in nucleic acid metabolism and/or interactions. It enables the rapid publication of papers under the following categories: Chemistry and synthetic biology; Computational biology; Gene regulation, chromatin and epigenetics; Genome integrity, repair and replication; Genomics; Molecular biology; Nucleic acid enzymes; RNA and Structural biology. A Survey and Summary section provides a format for brief reviews. The first issue of each year is devoted to biological databases, and an issue in July is devoted to papers describing web-based software resources of value to the biological community.

Oxford University Press
Impact factor
8.026 (2011)

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Hunt for interesting metabolites with the antiSMASH database

Scientists who hunt for interesting bacterial metabolites using the online tool antiSMASH now have the opportunity to use an antiSMASH database with pre-calculated results of nearly 25,000 bacterial genomes. This database ...

Discovery of rules for CRISPR advance metabolic engineering

Discovery of rules that govern a variation of the CRISPR/Cas9 gene-editing method makes it possible to use living cells to manufacture valuable metabolic compounds like pharmaceuticals and nutraceuticals. Researchers at Rensselaer ...

The artificial enzyme that "acts" natural

Certain genetic diseases arise from a deficit of specific genes. An enzyme that amplifies gene transcription could be a viable therapy in these cases, as long as genes are not stimulated to work on the wrong part of the body. ...

A new method simplifies the analysis of RNA structure

To understand the function of an RNA molecule, similar to the better-known DNA and vital for cell metabolism, we need to know its three-dimensional structure. Unfortunately, establishing the shape of an RNA strand is anything ...