Nature Structural & Molecular Biology is an integrated forum for structural and molecular studies. The journal places a strong emphasis on functional and mechanistic understanding of how molecular components in a biological process work together. Structural data may provide such insights, but they are not a pre-requisite for publication in the journal.

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Molecular sensor scouts DNA damage and supervises repair

In the time it takes you to read this sentence, every cell in your body suffers some form of DNA damage. Without vigilant repair, cancer would run rampant, and now scientists at the University of Pittsburgh have gotten a ...

Chemists discover structure of glucagon fibrils

Patients with type 1 diabetes have to regularly inject themselves with insulin, a hormone that helps their cells absorb glucose from the bloodstream. Another hormone called glucagon, which has the opposite effect, is given ...

A molecular hammock for cotranslational modification

Proteins do most of the real work in cells and are modified in accordance with functional requirements. An LMU team has now shown how proteins are chemically altered on the ribosome, even before they fold into the active ...

Biologists discover source for boosting tumor cell drug sensitivity

DNA-damaging agents, or "DDAs," make up the most widely used group of cancer drugs. Yet their therapeutic success has been curtailed by drug resistance—either present in cancer cells from the disease onset or arising during ...

Cryo-electron microscopy characterizes integrins

A collaboration between three labs at UC San Francisco has resulted in an unprecedented look at a member of a vital and ubiquitous class of proteins called integrins (pronounced "INT-uh-grins"). Integrins are associated with ...

Molecular movies of RNA guide drug discovery

Thumb through any old science textbook, and you'll likely find RNA described as little more than a means to an end, a kind of molecular scratch paper used to construct the proteins encoded in DNA.

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