Evidence for how a key transcription factor manages access to DNA

CTCF is a transcription factor that has been a research target due to its role in regulating a critical oncogene called MYC. Scientists at St. Jude Children's Research Hospital have found direct evidence that CTCF governs ...

Novel guidelines help select optimal deconvolution method

Biomedical scientists are increasingly using deconvolution methods, those used to computationally analyze the composition of complex mixtures of cells. One of their challenges is to select one method that is appropriate for ...

New method advances single-cell transcriptomic technologies

Single-cell transcriptomic methods allow scientists to study thousands of individual cells from living organisms, one-by-one, and sequence each cell's genetic material. Genes are activated differently in each cell type, giving ...

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