Genomics is a discipline in genetics concerned with the study of the genomes of organisms. The field includes efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping. The field also includes studies of intragenomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome. In contrast, the investigation of the roles and functions of single genes is a primary focus of molecular biology or genetics and is a common topic of modern medical and biological research. Research of single genes does not fall into the definition of genomics unless the aim of this genetic, pathway, and functional information analysis is to elucidate its effect on, place in, and response to the entire genome s networks. For the United States Environmental Protection Agency, "the term "genomics" encompasses a broader scope of scientific inquiry associated technologies than when genomics was initially considered. A genome is the sum total of all an individual organism s genes. Thus, genomics is the study of all the genes of a cell, or tissue, at the DNA (genotype), mRNA (transcriptome), or protein (proteome) levels." The

Publisher
BioMed Central
Country
United Kingdom
History
2000–present
Website
http://genomebiology.com
Impact factor
6.89 (2011)

Some content from Wikipedia, licensed under CC BY-SA

Unlocking the secrets of plant genomes in high resolution

Resolving genomes, particularly plant genomes, is a very complex and error-prone task. This is because there are several copies of all of the chromosomes and they are very alike. A team of bioinformatics researchers from ...

Study reveals DNA 'grammar'

DNA three-dimensional structure is determined by a series of spatial rules based on particular protein sequences and their order. This was the finding of a study recently published in Genome Biology by Luca Nanni, Ph.D. student ...

Barcoding long DNA quantifies CRISPR effects

Current sequencing techniques lack the sensitivity to detect rare gene mutations in a pool of cells, which is particularly important, for example, in early cancer detection. Now, scientists at KAUST have developed an approach, ...

page 1 from 14