Genomics is a discipline in genetics concerned with the study of the genomes of organisms. The field includes efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping. The field also includes studies of intragenomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome. In contrast, the investigation of the roles and functions of single genes is a primary focus of molecular biology or genetics and is a common topic of modern medical and biological research. Research of single genes does not fall into the definition of genomics unless the aim of this genetic, pathway, and functional information analysis is to elucidate its effect on, place in, and response to the entire genome s networks. For the United States Environmental Protection Agency, "the term "genomics" encompasses a broader scope of scientific inquiry associated technologies than when genomics was initially considered. A genome is the sum total of all an individual organism s genes. Thus, genomics is the study of all the genes of a cell, or tissue, at the DNA (genotype), mRNA (transcriptome), or protein (proteome) levels." The

Publisher
BioMed Central
Country
United Kingdom
History
2000–present
Website
http://genomebiology.com
Impact factor
6.89 (2011)

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A new global study reveals the extent to which high-yielding rice varieties favored in the decades since the "Green Revolution" have a propensity to go feral, turning a staple food crop into a weedy scourge.

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'Jumping genes' help stabilize DNA folding patterns

"Jumping genes"—bits of DNA that can move from one spot in the genome to another—are well-known for increasing genetic diversity over the long course of evolution. Now, new research at Washington University School of ...

New tool reveals DNA structures that influence disease

Disruption of certain DNA structures—called topologically associating domains, or TADs—is linked with the development of disease, including some cancers. With its newly created algorithm that quickly locates and helps ...

A way to 'fingerprint' human cells

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Swiss army knife for genome research

It is the the dream of every molecular geneticist: an easy-to-use program that compares datasets from different cellular conditions, identifies enhancer regions and then assigns them to their target genes. A research team ...

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