Genomics is a discipline in genetics concerned with the study of the genomes of organisms. The field includes efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping. The field also includes studies of intragenomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome. In contrast, the investigation of the roles and functions of single genes is a primary focus of molecular biology or genetics and is a common topic of modern medical and biological research. Research of single genes does not fall into the definition of genomics unless the aim of this genetic, pathway, and functional information analysis is to elucidate its effect on, place in, and response to the entire genome s networks. For the United States Environmental Protection Agency, "the term "genomics" encompasses a broader scope of scientific inquiry associated technologies than when genomics was initially considered. A genome is the sum total of all an individual organism s genes. Thus, genomics is the study of all the genes of a cell, or tissue, at the DNA (genotype), mRNA (transcriptome), or protein (proteome) levels." The

Publisher
BioMed Central
Country
United Kingdom
History
2000–present
Website
http://genomebiology.com
Impact factor
6.89 (2011)

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Directed evolution comes to plants

A new platform for speeding up and controlling the evolution of proteins inside living plants has been developed by a KAUST-led team.

How genes interact to build tissues and organisms

Although the knowledge we have about human cells and tissues has steadily increased over recent decades, many things remain unknown. For instance, cells exist in transient, dynamic states and understanding them is fundamental ...

African populations crossbred with other extinct humans

A new international study led by David Comas, principal investigator at UPFand at the Institute of Evolutionary Biology (IBE: CSIC-UPF), demonstrates for the first time using artificial intelligence that African populations ...

BRB-seq: The quick and cheaper future of RNA sequencing

RNA sequencing is a technique used to analyze entire genomes by looking at the expression of their genes. Today, such genome-wide expression analyses are a standard tool for genomic studies because they rely on high-throughput ...

Clear sight in the data fog with PAGA

Experimental molecular assays with single-cell resolution generate big and complex data. Researchers at Helmholtz Zentrum München and the Technical University of Munich are now presenting their computer algorithm PAGA. They ...

Single cell transcriptomics: A new sequencing approach

Researchers from University of Southern Denmark, Wellcome Sanger Institute and BGI have published a study in the journal Genome Biology comparing the library preparation and sequencing platforms for single-cell RNA-sequencing ...

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