Structure of the kinetochore corona finally revealed

During cell division in a mother cell, the 23 chromosomes that carry the human genome must be first copied and later delivered to two newly forming daughter cells. At least in healthy cells, the result is astonishingly flawless, ...

Deadly combination: New direct trigger for cell death discovered

Scientists led by Professor Ana J. Garcia-Saez at the CECAD Cluster of Excellence for Aging Research at the University of Cologne have shown that apoptosis, the programmed cell death, involves a direct physical interplay ...

Bacterial genome is regulated by an ancient molecule

We are all collections of cells, each cell containing the instructions—our DNA—to become any other cell. What differentiates a heart cell from a skin cell from a brain cell is the expression—or silencing—of genes.

How plants respond to heat stress

Plants, like other organisms, can be severely affected by heat stress. To increase their chances of survival, they activate the heat shock response, a molecular pathway also employed by human and animal cells for stress protection. ...

Old protein, new function: tBID can directly trigger cell death

The protein tBID can trigger programmed cell death (apoptosis) by inducing damage in the energy suppliers of the cells, the mitochondria. Apoptosis is essential for maintaining tissue balance. In addition, apoptosis plays ...

Autophagy in major human diseases

In a consensus article, Federico Pietrocola, at the Department of Biosciences and Nutrition, KI, and colleagues explore the pathophysiological relevance of autophagy in human illnesses, while highlighting the therapeutic ...

Neutralizing the SARS-CoV-2 sugar coat

Researchers have identified two sugar-binding proteins that impede the viral entry of circulating SARS-CoV-2 variants. The team, spearheaded by researchers at IMBA—Institute of Molecular Biotechnology of the Austrian Academy ...

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