Cell Stem Cell is a broad-spectrum journal that covers the entire spectrum of stem cell biology. Topics covered include embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, stem cell differentiation, epigenetics, stem cell genomics and systems biology, genome reprogramming, cancer stem cells, stem cell niches, stem-cell-based disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging of stem cells, therapeutic applications, regenerative medicine, clinical and translational insights, stem cell research policies, ethical issues, and technical or resource-based innovations. We will consider studies from any model system that provides insights into stem cell biology, and we encourage submissions on human stem cells.
'CRISPR' science: Newer genome editing tool shows promise in engineering human stem cells
A powerful "genome editing" technology known as CRISPR has been used by researchers since 2012 to trim, disrupt, replace or add to sequences of an organism's DNA. Now, scientists at Johns Hopkins Medicine have shown that ...
Jan 05, 2015
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Lab-created mini-brains reveal how growing organ maintains neuronal balance
Scientists can now explore in a laboratory dish how the human brain develops by creating organoids—distinct, three-dimensional regions of the brain. In research published in Cell Stem Cell, Yale scientists coaxed early ...
Researchers glimpse elusive stem cell in the early embryo
Stem cell researchers at Harvard Medical School and Boston Children's Hospital have, for the first time, profiled a highly elusive kind of stem cell in the early embryo—a cell so fleeting that it makes its entrance and ...
Using single-cell RNA sequencing and clever statistical analysis to track stem cells as they mature
Adult stem cells have the ability to transform into many types of cells, but tracing the path individual stem cells follow as they mature and identifying the molecules that trigger these fateful decisions are difficult in ...
Research papers shed light on decade-long stem cell mystery
A series of studies led by Monash University researcher Associate Professor Jose Polo have this week shed light on vital, yet previously unclear, aspects of cell reprogramming.
Researchers transform common cell to master heart cell
By genetically reprogramming the most common type of cell in mammalian connective tissue, researchers at the University of Wisconsin-Madison have generated master heart cells—primitive progenitors that form the developing ...
Bioengineers show why lab-made stem cells might fail: Errors in DNA folding
Induced pluripotent stem cells hold promise for regenerative medicine because they can, in theory, turn into any type of tissue and because they are made from a patient's own adult cells, guaranteeing compatibility. However, ...
New tools to study the origin of embryonic stem cells
Researchers at Karolinska Institutet have identified cell surface markers specific for the very earliest stem cells in the human embryo. These cells are thought to possess great potential for replacing damaged tissue but ...
Tbx6 revealed as crucial to heart and skeleton formation from stem cells
Many studies have attempted to identify a single transcription factor that can induce formation of the mesoderm, an early layer in embryonic development, without help from other cellular proteins. None have been successful, ...
Mature cells revert to stem cells to boost tissue regeneration and repair in mouse intestines
Researchers at Harvard Stem Cell Institute, Dana-Farber Cancer Institute, and Harvard Medical School have identified a previously unknown mechanism that plays an important role in the regeneration of the inner intestinal ...
