Queen's University expert leading 4m bid to reduce impact of chemicals on long-term health

A Queen's University Belfast expert is leading a €4m international initiative to investigate whether natural toxins and manmade chemicals are creating potentially dangerous mixtures that affect our natural hormones and cause major illnesses such as cancer, obesity, diabetes or infertility.

These chemicals include natural fungal toxins which can contaminate food and manmade chemicals such as pesticides.

Dr Lisa Connolly, a leading academic in Toxin Food Safety and an expert in the Bioassay Analysis of Endocrine Disruptors at the University's Institute for Global Food Security, will lead the European Commission Funded study and collaborate with global experts in an international consortium involving thirteen organisations across nine countries to tackle the world-wide challenge.

The four-year Marie Curie Innovative Training Network project PROTECTED (PROTECTion against Endocrine Disruptors) begins in January 2017 and the search is already underway for fifteen early stage researchers who will be trained as world class researchers that can develop innovative and entrepreneurial ways of dealing with this global challenge.

Dr Connolly said: "Currently there is a world-wide shortage of researchers who can assess the impact of potentially dangerous natural and manmade endocrine disrupting chemicals and their mixtures on the hormone system which controls important functions within the body such as growth, development and fertility. We also need to understand whether these chemicals can cause illness by damaging the health of good bacteria in the gut."

"Endocrine disruptors are suspected factors and sometimes proven agents behind several major human diseases, poor productivity in agricultural animals and stress upon ecosystems. If we can identify chemicals and mixtures of concern, we can use this knowledge to inform legislators, improve monitoring and reduce exposure."

Queen's University Belfast will be awarded €1.2m of the funding with three researchers based at its world-leading Institute for Global Food Security. With its excellent academic record in food security and health, Queen's University Belfast is ideally suited for co-ordinating the project, further strengthening its leadership position in this field internationally.

Dr Connolly added: "The exact effects of endocrine disruptors are difficult to assess so far because of the complexity of the chemical mixtures involved and the lack of efficient methods to assess their effects.

"This newly established consortium is an exciting opportunity as it provides unique, world-leading and cutting-edge training for a new generation of experts who will have the ability to develop innovative analysis tools which will help protect the world from the real-life risks of these chemicals, improving health now and in the future."

Speaking on behalf of all 13 organisations, Dr Marc Muller from Liege University in Belgium, said: "This expert approach is radically multi-disciplinary and deals with human or animal health using analytical chemistry, cellular tests and risk assessment of mixture effects."

Professor Paul Fowler, from the University of Aberdeen in Scotland, added: "This exciting project and expert training network includes a crucial focus on human pregnancy. This is important because of the susceptibility of the developing baby in the womb to chemicals."

Dr Connolly is collaborating with global experts in this international consortium including the Norwegian Institute for Public Health (Norway), the University of Aberdeen (Scotland), the Norwegian University of Life Sciences (Norway), The National Institute for Agricultural Research (France), the University Austral (Chile), the Norwegian Veterinary Institute (Norway), the University of Liege (Belgium), BioDetection Systems - an in vitro bioassay company based in The Netherlands, ProtoQSAR SL - a chemoinformatics & molecular modeling company in Spain, John Thompson & Sons Ltd - an animal feed company based in Northern Ireland, La Societe Wallone des Eaux - a water supplier in Belgium, and the Public Health Foundation of India.

Provided by Queen's University Belfast