This Science News Wire page contains a press release issued by an organization and is provided to you "as is" with little or no review from Science X staff.

Zhichan decoction increases dopaminergic neurons from transplanted NSCs in PD

July 16th, 2014

There is an increasing interest in Parkinson's disease (PD) treatment by increasing dopamine content and reducing dopaminergic metabolites in the brain. Xuming Yang, Shanghai Municipal Hospital of Traditional Chinese Medicine, China and his team detected dopamine content and dopaminergic metabolites in the midbrain of PD rats, which were treated by neural stem cell (NSC) transplantation and Zhichan decoction administration, using high-performance liquid chromatography, and determined global optimization of dihydroxyphenylacetic acid and homovanillic acid levels using genetic algorithm. Results showed that NSC transplantation and Zhichan decoction administration increased dihydroxyphenylacetic acid levels up to 10-fold, while NSC transplantation alone resulted in a 3-fold increment. Homovanillic acid levels showed no apparent change.

These findings indicate that after NSC transplantation in PD rats, Zhichan decoction can promote differentiation of NSCs into dopaminergic neurons. Related results were published in Neural Regeneration Research (Vol. 9, No. 9, 2014).

More information:
Zhichan decoction induces differentiation of dopaminergic neurons in Parkinson's disease rats after neural stem cell transplantation. Neural Regen Res. 2014;9(9):931-936.

Provided by Neural Regeneration Research

Citation: Zhichan decoction increases dopaminergic neurons from transplanted NSCs in PD (2014, July 16) retrieved 19 April 2024 from https://sciencex.com/wire-news/166956511/zhichan-decoction-increases-dopaminergic-neurons-from-transplant.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.