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Atorvastatin protects against cerebral ischemia/reperfusion injury

April 23rd, 2014
Atorvastatin protects against cerebral ischemia/reperfusion injury
Diffusion tensor imaging showed that lesions were reduced and fractional anisotropy values decreased in patients with diffuse axonal injury after mild hypothermia therapy compared with normothermia therapy. Credit: Neural Regeneration Research

In addition to its lipid-lowering effect, statins exert anti-inflammatory and antioxidant effects as well. Statins also provide protection against renal, pulmonary and myocardial ischemia/reperfusion injury. However, little evidence is available on similar changes in cerebral ischemia/reperfusion injury.

Therefore, Dr. Qiuyun Tu and colleagues from Third Xiangya Hospital of Central South University in China verified that atorvastatin, a commonly used lipid-lowering drug, protects against cerebral ischemia/reperfusion injury through anti-infammatory and antioxidant effects.

The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 3, 2014).

More information:
Tu QY, Cao H, Zhong W, Ding BR, Tang XQ. Atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects. Neural Regen Res. 2014;9(3):268-275.

Provided by Neural Regeneration Research

Citation: Atorvastatin protects against cerebral ischemia/reperfusion injury (2014, April 23) retrieved 26 April 2024 from https://sciencex.com/wire-news/159701594/atorvastatin-protects-against-cerebral-ischemiareperfusion-injur.html
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