A team led by Prof. Yingbin Li from the Second Affiliated Hospital of Nanjing Medical University, China found that doxycycline-induced neural stem cells in the subventricular zone of c-myc+/SV40Tag+/Tet-on+ transgenic mice have increased proliferative activity and inhibitory differentiation similar to tumor stem cells, suggesting that neural stem cells have a tendency for malignant transformation, and could be a source of tumor stem cells.
These findings were published in the Neural Regeneration Research (Vol. 8, No. 25, 2013).
Qiao GQ, Li QQ, Peng G, Ma J, Fan HW, Li YB. Similarity on neural stem cells and brain tumor stem cells in transgenic brain tumor mouse models. Neural Regen Res. 2013;8(25):2360-2369.
Provided by Neural Regeneration Research
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