Did brain tumor stem cells originate from malignant neural stem cells?

October 29th, 2013
Did brain tumor stem cells originate from malignant neural stem cells?
This image shows an identification of normal neural stem cells (NNSCs), induced neural stem cells (INSCs) and brain tumor stem cells (BTSCs). NNSCs and INSCs were derived from the subventricular zone tissue of non-induced and induced transgenic mice. BTSCs were derived from brain tumor tissue of the induced transgenic mouse. (A) Co-expression of nestin and 5-bromo-2'-deoxyuridine in brain tumor stem cells derived from brain tumor tissue of the induced c-myc+/SV40Tag+/Tet-on+ transgenic mouse (immunofluorescence, bars: 20 µm). Credit: Neural Regeneration Research
Although it is believed that glioma is derived from brain tumor stem cells, the source and molecular signal pathways of these cells are still unclear. The potential of neural stem cells to transform into brain tumor stem cells has long been considered, but has not been confirmed.

A team led by Prof. Yingbin Li from the Second Affiliated Hospital of Nanjing Medical University, China found that doxycycline-induced neural stem cells in the subventricular zone of c-myc+/SV40Tag+/Tet-on+ transgenic mice have increased proliferative activity and inhibitory differentiation similar to tumor stem cells, suggesting that neural stem cells have a tendency for malignant transformation, and could be a source of tumor stem cells.

These findings were published in the Neural Regeneration Research (Vol. 8, No. 25, 2013).

More information:
Qiao GQ, Li QQ, Peng G, Ma J, Fan HW, Li YB. Similarity on neural stem cells and brain tumor stem cells in transgenic brain tumor mouse models. Neural Regen Res. 2013;8(25):2360-2369.

Provided by Neural Regeneration Research

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