$6.4 million grant funds glaucoma study in African-Americans

October 11th, 2013
$6.4 million grant funds glaucoma study in African-Americans
This is an eye with glaucoma. Credit: NA
A study led by Robert N. Weinreb, chairman and Distinguished Professor of Ophthalmology at the University of California, San Diego School of Medicine, has received a $6.4 million, 5-year grant from the National Eye Institute, part of the National Institutes of Health, to elucidate the genetics of glaucoma in persons of African descent.

Glaucoma is the leading cause of blindness in African-Americans. It is four to five times more likely to occur in persons of African descent, and up to 15 times more likely to cause meaningful visual impairment in this group compared to those of European descent.

The overall goal of the study, "ADAGES III: contribution of genotype to glaucoma phenotype in African-Americans," is to identify glaucoma genes in this high-risk, minority population, particularly persons who have rapidly worsening vision. Weinreb has teamed with Jerry Rotter, MD, Distinguished Professor of Pediatrics, Medicine and Human Genetics at Harbor-UCLA Medical Center, a renowned genetics expert, to identify relevant genes, develop predictive models for glaucoma diagnosis and progression and discover new drug targets for therapies to reduce the visual impact of glaucoma blindness.

Glaucoma results in vision loss due to damage to the optic nerve, which is irreversible if undetected or untreated. The most common form of glaucoma is called primary open angle glaucoma (POAG). The number of persons with diagnosed POAG in the United States is expected to be more 3.3 million by 2020, with millions more undiagnosed. While glaucoma affects all races, persons of African descent are disproportionately affected.

"The lack of understanding about the cause of this disease impedes our ability to identify and treat it early in its development," said Weinreb, who is also director of the Shiley Eye Center, part of the UC San Diego Health System. "Evidence of genetic contribution in the pathogenesis of POAG is well established. Since POAG tends to run in families, it is critical to identify the genetic basis of the disease in order to develop effective therapies for early intervention."

"A better understanding of the relationship among the stage of disease, the rate of change, ancestry, and other important risk factors being tracked in the ongoing African Descent and Glaucoma Study (ADAGES) will allow us to evaluate the relationship between genetics, visual loss and structural damage in this high-risk group," added Linda Zangwil, PhD, a professor of ophthalmology at UC San Diego and study co-investigator.

The study will obtain detailed phenotypes – a composite of all observed characteristics or traits of an individual – of more than 2,000 subjects, establish a repository and implement a data-coordinating center at UC San Diego, as well conduct comprehensive genetic studies.

The recruitment, enrollment and phenotyping of both established and new subjects will occur at four clinical centers: UC San Diego School of Medicine; New York Eye and Ear Infirmary; University of Alabama at Birmingham; and a private practice in the Atlanta, Ga. area.

ADAGES III is funded by NIH grant RO1EY023704.

Provided by University of California - San Diego

This Phys.org Science News Wire page contains a press release issued by an organization mentioned above and is provided to you “as is” with little or no review from Phys.Org staff.

More news stories

Mechanism for aprotic sodium-air batteries

The automobile industry has been interested in finding batteries that allow electric cars to travel at a comparable distance to gas-powered cars. Currently, electric cars use a lithium ion battery, but there ...

Cheetah robot lands the running jump (w/ Video)

In a leap for robot development, the MIT researchers who built a robotic cheetah have now trained it to see and jump over hurdles as it runs—making this the first four-legged robot to run and jump over ...

Project Jacquard to weave interactivity into textiles

"Wearables" represents a broad-category of how we will interact with the digital world away from our laptop screens. It embraces arm bands, socks, bracelets, rings and watches. Google is now enhancing that ...

New 'designer carbon' boosts battery performance

Stanford University scientists have created a new carbon material that significantly boosts the performance of energy-storage technologies. Their results are featured on the cover of the journal ACS Central Sc ...

Herschel's hunt for filaments in the Milky Way

Observations with ESA's Herschel space observatory have revealed that our Galaxy is threaded with filamentary structures on every length scale. From nearby clouds hosting tangles of filaments a few light-years ...

Chemical deterrent from snow fleas identified

Snow fleas keep predators at bay with a chemical deterrent. German scientists have now isolated this compound and identified it by means of spectroscopic analysis and X-ray crystallography. In the journal ...