(Phys.org) —By loading any specific protein and nucleic acid into an icosahedral phage T4 capsid-based nanoparticle, the resulting cell delivery vehicle's ligands can bind to the surface of specific target tissues to deliver ...
Recurrent infection is a common feature of persistent viral diseases. It includes episodes of high viral production interspersed by periods of relative quiescence. These quiescent or silent stages are hard to study with experimental ...
Mathematics
May 31, 2013
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New tools for editing genetic code offer hope for new treatments for inherited diseases, some cancers, and even stubborn viral infections. But the typical method for delivering gene therapies to specific tissues in the body ...
Bio & Medicine
Sep 9, 2019
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160
Researchers have recreated the evolutionary lineage of adeno-associated viruses (AAVs) to reconstruct an ancient viral particle that is highly effective at delivering gene therapies targeting the liver, muscle, and retina. ...
Cell & Microbiology
Jul 30, 2015
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107
Rice University researchers are making strides toward a set of rules to custom-design Lego-like viral capsid proteins for gene therapy.
Biotechnology
Aug 12, 2013
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Within a virus's tiny exterior is a store of energy waiting to be unleashed. When the virus encounters a host cell, this pent-up energy is released, propelling the viral DNA into the cell and turning it into a virus factory. ...
Cell & Microbiology
Feb 5, 2010
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Researchers from Johns Hopkins and Northwestern universities have discovered how to control the shape of nanoparticles that move DNA through the body and have shown that the shapes of these carriers may make a big difference ...
Bio & Medicine
Oct 12, 2012
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Australian scientists have successfully found a way to inject beneficial genetic material into white blood cells in a world-first breakthrough that could significantly improve treatment options for certain types of blood ...
Bio & Medicine
Aug 24, 2023
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Reversing a protein deficiency through gene therapy can correct motor function, restore nerve signals and improve survival in mice that serve as a model for the lethal childhood disorder spinal muscular atrophy, new research ...
Biotechnology
Feb 28, 2010
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37 million people around the world today live with Human Immunodeficiency Virus (HIV), which is responsible for roughly 1.1 million deaths caused by AIDS-related conditions.
Mathematics
Oct 19, 2017
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