A particular tumor suppressor gene that fights cancer cells does more than clamp down on unabated cell division—the hallmark of the disease—it also can help make cells more fit by allowing them to fend ...
May 10, 2013
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(Phys.org)—Researchers at Michigan State University have discovered a protein that does its best work with one foot in the grave.
Dec 12, 2012
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A team of researchers from the Spanish National Cancer Research Centre (CNIO), led by Manuel Serrano, from the Tumour Suppression Group, together with scientists from London and Santiago de Compostela, has discovered that ...
Dec 06, 2012
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Researchers have shown for the first time that the protein fortilin promotes growth of cancer cells by binding to and rendering inert protein p53, a known tumor suppressor. This finding by researchers at the University of ...
Sep 16, 2011
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A cancer cell may seem out of control, growing wildly and breaking all the rules of orderly cell life and death. But amid the seeming chaos there is a balance between a cancer cell's revved-up metabolism and skyrocketing ...
Jul 13, 2011
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Tumor suppressor genes normally control the growth of cells, but cancer can spring up when these genes are silenced by certain chemical reactions that modify chromosomes. Among the most common culprits responsible for inactivating ...
Apr 05, 2011
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Researchers offer the first evidence that DNA damage can lead to the regulation of inflammatory responses, the body's reaction to injury. The proteins involved in the regulation help protect the body from infection.
Mar 31, 2011
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(PhysOrg.com) -- How do organs "know" when to stop growing? The answer could be useful in regenerative medicine, and also in cancer - where these "stop growing" signals either aren't issued or aren't heeded. Researchers in ...
Mar 09, 2011
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Burkitt's lymphoma is one of the most aggressive tumors affecting humans. Multiple alterations in genes that regulate cell proliferation rate explain its aggressive behavior.
Mar 07, 2011
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The gene for the protein p53 is the most frequently mutated in human cancer. It encodes a tumor suppressor, and traditionally researchers have assumed that it acts primarily as a regulator of how genes are ...
Mar 02, 2011
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A new study sheds light on why individuals who inherit a particular family of mutations have a high risk of developing a very aggressive form of breast cancer. The research, published by Cell Press on February 4th in the ...
Feb 03, 2011
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Researchers from the Kimmel Cancer Center at Jefferson and two other institutions have discovered new evidence that suggests the "longevity" protein SIRT1, known for its life-spanning effects in different species, can inhibit ...
Jan 13, 2011
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Squamous cell carcinoma (SCC) is a common type of skin cancer. In this paper, Leif Ellisen and colleagues at Mass General Hospital investigated the p53-related proteins p63 and p73 in SCC cells, and discovered a feedback ...
Jan 10, 2011
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Researchers have discovered a method for more precise identification of individuals who should undergo testing for genetic mutations of the tumor suppressor gene PTEN, which associates with a variety of conditions including ...
Jan 10, 2011
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The interplay between a major tumor-suppressing gene, a truncated chromosome and two sets of microRNAs provides a molecular basis for explaining the less aggressive form of chronic lymphocytic leukemia, an international team ...
Jan 07, 2011
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