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Novel role for metabolites in cellular metabolism discovered

Investigators led by Issam Ben-Sahra, Ph.D., associate professor of Biochemistry and Molecular Genetics, have discovered how cellular metabolism fluctuates in response to changes in levels of pyrimidines, metabolites used ...

Transforming growth factor

Transforming growth factor (sometimes referred to as Tumor growth factor, or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGFβ.

The name "Transforming Growth Factor" is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor mechanisms. Furthermore, they do not always induce cellular transformation, and are not the only growth factors that induce cellular transformation.

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