Decoding the molecular networks of early human development

New international research shines a light on the role of transcription factors during early embryonic development. Transcription factors are proteins that are critical for gene regulation. The study unveiled more than 1,000 ...

How chemical modifications on DNA keep genes silent

Several diseases, including certain types of cancer and some neurodevelopmental conditions, have aberrant patterns of DNA methylation, a chemical modification that regulates gene expression in ways that keep genes in the ...

New way to target 'undruggable' molecules involved in cancer

For decades, cancer researchers have longed for a way to target a set of proteins called transcription factors. While we've long known that tumors use these proteins to grow out of control, their unique configurations meant ...

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