New method knocks out yeast genes with single-point precision

How do you make yeast work harder? Not to make bread, but in processes that yield chemicals and pharmaceuticals. Industries currently use a yeast called Saccharomyces cerevisiae. They'd like it to work better. The answer ...

Complex networks identify genes for biofuel crops

To improve biofuel production, scientists must understand the fundamental interactions that lead to the expression of key traits in plants and microbes. To understand these interactions, scientists are using different layers ...

Scientists improve DNA transfer in gene therapy

Parkinson's disease, Huntington's disease, cystic fibrosis and many other fatal human diseases are hereditary. Many cancers and cardiovascular diseases are also caused by genetic defects. Gene therapy is a promising possibility ...

Using networks to understand tissue-specific gene regulation

Researchers at Brigham and Women's Hospital have discerned that different tissue functions arise from a core biological machinery that is largely shared across tissues, rather than from their own individual regulators. In ...

Matchmaking with consequences

Most human tumours have one thing in common: They harbour drastically increased amounts of the so-called Myc proteins. Animal experiments show that such high Myc concentrations contribute to causing cancer. But Myc proteins ...

Plant cells survive but stop dividing upon DNA damage

The cell cycle is the system through which a cell grows and divides. It is also how a cell passes its DNA to its progeny and is why the cell cycle ceases if the DNA is damaged, as otherwise it risks passing this damage to ...

Scientists use CRISPR technology to change flower colour

In a world-first, Japanese scientists have used the revolutionary CRISPR, or CRISPR/Cas9, genome- editing tool to change flower colour in an ornamental plant. Researchers from the University of Tsukuba, the National Agriculture ...

How the genome sets its functional micro-architecture

The genes that are involved in the development of the fetus are activated in different tissues and at different times. Their expression is carefully regulated by so-called "enhancer sequences", which are often located far ...

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