News tagged with tamoxifen
Breast cancer drug shows promise against serious infections
An FDA-approved drug used for preventing recurrence of breast cancer shows promise in fighting life-threatening fungal infections common in immune-compromised patients, such as infants born prematurely and patients with cancer. ...
Jul 20, 2009 |
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Clue to unusual drug-resistant breast cancers found
Researchers at the University of Illinois at Chicago College of Medicine have found how gene expression that may contribute to drug resistance is ramped up in unusual types of breast tumors. Their findings may offer new therapy ...
Oct 08, 2010 |
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HOXB7 gene promotes tamoxifen resistance
Many postmenopausal women with early-stage breast cancers who initially respond well to tamoxifen become resistant to the drug over time and develop recurrent tumors. Johns Hopkins Kimmel Cancer Center researchers have found ...
Dec 11, 2010 |
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Anti-estrogen medication reduces risk of dying from lung cancer
A new study has found that tamoxifen, an anti-estrogen breast cancer medication, may reduce an individual's risk of death from lung cancer. Published early online in Cancer, a peer-reviewed journal of the American Cancer ...
Jan 24, 2011 |
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Switching early breast cancer patients to exemestane improves long-term survival
New research has found that switching post-menopausal women with early breast cancer to the drug exemestane (Aromasin) after two or three years of tamoxifen rather than keeping them on tamoxifen for five years improves the ...
Sep 21, 2009 |
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Study: 2 good choices to prevent breast cancer
(AP) -- Older women at higher risk for breast cancer now have two good drug options for preventing the disease, but they will have to weigh the trade-offs, a major study shows.
Apr 19, 2010 |
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Scientists discover five new genome regions that increase breast cancer risk
(PhysOrg.com) -- Scientists have found five new regions of the genome that increase a woman's risk of developing breast cancer by between 6 and 16 per cent, according to a study published in the journal 'Nature ...
May 11, 2010 |
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Cough medicine could help doctors identify how breast cancer patients metabolize tamoxifen
Cough medicine could be used as way of predicting how well individual patients metabolise tamoxifen used in the treatment of their breast cancer, according to new research presented at the 22nd EORTC-NCI-AACR Symposium on ...
Nov 19, 2010 |
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Getting more anti-cancer medicine into the blood
Scientists are reporting successful application of the technology used in home devices to clean jewelry, dentures, and other items to make anticancer drugs like tamoxifen and paclitaxel dissolve more easily in body fluids, ...
Jan 26, 2011 |
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Taking tamoxifen to prevent breast cancer can save lives and money
Tamoxifen, taken by certain women as a preventive measure against breast cancer, saves lives and reduces medical costs. That is the conclusion of a new study published early online in Cancer, a peer-reviewed journal of the ...
Mar 14, 2011 |
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High-risk women reluctant to take tamoxifen to prevent breast cancer, study finds
Even when women at high-risk of breast cancer are well-informed about the risks and benefits of using the drug tamoxifen for prevention, only 6 percent said they were likely to take it.
Dec 03, 2009 |
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Tamoxifen
Tamoxifen is an antagonist of the estrogen receptor in breast tissue and is therefore used in the treatment of breast cancer. As of 2004, it was the world's largest selling drug for that purpose.
Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Furthermore tamoxifen prevents estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.
Tamoxifen was discovered by ICI Pharmaceuticals (now AstraZeneca) and is sold under the trade names Nolvadex, Istubal, and Valodex. However, the drug, even before its patent expiration, was and still is widely referred to by its generic name "tamoxifen."
For more information about Tamoxifen, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
