A microbial sensor that helps identify and fight bacterial infections also plays a key role in the development of blood stem cells, providing a valuable new insight in the effort to create patient-derived blood stem cells ...
Cell & Microbiology
Dec 19, 2023
0
96
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA are one step closer to developing stem cell therapies to regenerate skeletal muscle in humans. Working in mice, the UCLA ...
Cell & Microbiology
Nov 2, 2023
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115
A readily available, inexpensive, small molecule drug can improve the fitness of hematopoietic stem and progenitor cells (HSPCs) that are modified outside the body, potentially improving the success of procedures such as ...
Cell & Microbiology
Sep 27, 2023
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1
A team of bioengineers and biomedical scientists from the University of Sydney and the Children's Medical Research Institute (CMRI) at Westmead have used 3D photolithographic printing to create a complex environment for assembling ...
Biotechnology
Aug 11, 2023
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362
In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept ...
Biotechnology
Jul 27, 2023
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69
Cells in the blood such as immune cells, red blood cells and other vital cell types are constantly renewed from stem cells, the so-called hematopoietic stem and progenitor cells (HSPCs). Certain diseases of the blood system, ...
Cell & Microbiology
Feb 17, 2023
0
11
Stem cells from umbilical cords in Skåne are improved with nanotubes. By cross-pollinating nanotechnology with stem cell biology, researchers are creating gentle methods to ensure that more cells perform better. Blood stem ...
Cell & Microbiology
Jan 3, 2023
0
17
Enhancement of adhesion molecules improves the ability of blood-forming stem cells to take root in transplant recipients.
Cell & Microbiology
Aug 25, 2022
0
13
The origins of our blood may not be quite what we thought. Using cellular "barcoding" in mice, a groundbreaking study finds that blood cells originate not from one type of mother cell, but two, with potential implications ...
Cell & Microbiology
Jun 15, 2022
0
136
Blood-forming stem cells found in bone marrow are the life-saving component used in bone marrow transplants. However, suitable donors cannot be found in many cases. A new study reveals how the human embryo develops the precursor ...
Cell & Microbiology
Apr 28, 2022
0
67
Hematopoietic stem cell transplantation (HSCT) is the transplantation of blood stem cells derived from the bone marrow (in this case known as bone marrow transplantation) or blood. Stem cell transplantation is a medical procedure in the fields of hematology and oncology, most often performed for people with diseases of the blood, bone marrow, or certain types of cancer.
With the availability of the stem cell growth factors GM-CSF and G-CSF, most hematopoietic stem cell transplantation procedures are now performed using stem cells collected from the peripheral blood, rather than from the bone marrow. Collecting peripheral blood stem cells provides a bigger graft, does not require that the donor be subjected to general anesthesia to collect the graft, results in a shorter time to engraftment, and may provide for a lower long-term relapse rate.
Hematopoietic stem cell transplantation remains a risky procedure with many possible complications; it has traditionally been reserved for patients with life-threatening diseases. While occasionally used experimentally in nonmalignant and nonhematologic indications such as severe disabling auto-immune disease and cardiovascular disease, the risk of fatal complications appears too high to gain wider acceptance.
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