Evolution: Alternative splicing of RNA rewires signaling in different tissues, may contribute to species differences
Scientists create new approach to destroy disease-associated RNAs in cells
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new approach to alter the function of RNA in living cells by designing molecules that recognize and disable RNA targets. As a proof ...
Dec 20, 2012
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New study finds that one key mechanism in development involves 'paused' RNA polymerase
For a tiny embryo to grow into an entire fruit fly, mouse or human, the correct genes in each cell must turn on and off in precisely the right sequence. This intricate molecular dance produces the many parts of the whole ...
Dec 20, 2012
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Survival of the females
It is well known that many mammals are able to adjust the ratio of male and female young depending on the surrounding conditions at the time of conception. A recent study in the group of Christine Aurich ...
Dec 18, 2012
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Raising the blockade
At crucial points in the metabolism of all organisms, a protein with the unwieldy name of Translation Elongation Factor P (EF-P, for short) takes center stage. What it actually does during protein synthesis has only now been ...
Dec 14, 2012
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Crowdsourcing to kickstart comeback from ash dieback
On Friday scientists from The Sainsbury Laboratory and the John Innes Centre will publish the first RNA sequence data on the ash dieback fungus causing an epidemic of disease.
Dec 14, 2012
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Transposable elements reveal a stem cell specific class of long noncoding RNAs
Over a decade after sequencing the human genome, it has now become clear that the genome is not mostly 'junk' as previously thought. In fact, the ENCODE project consortium of dozens of labs and petabytes of data have determined ...
Nov 26, 2012
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Researchers develop mRNA based flu vaccine
(Phys.org)—A joint research effort by the Friedrich-Loeffler-Institute and pharmaceutical company CureVac, both based in Germany, has resulted in the creation of a new type of flu vaccine. The vaccine, as the team describes ...
Nov 26, 2012
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RNA folding: A little cooperation goes a long way
(Phys.org)—The nucleic acid RNA is an essential part of the critical process by which the cells in our bodies manufacture proteins. But noncoding RNAs also exist whose sequences, while not converted into ...
Nov 21, 2012
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More than a machine: Ribosome regulates viral protein synthesis, revealing potential therapeutic target
Viruses can be elusive quarry. RNA viruses are particularly adept at defeating antiviral drugs because they are so inaccurate in making copies of themselves. With at least one error in every genome they copy, viral genomes ...
Nov 20, 2012
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Scientists show protein-making machinery can switch gears with a small structural change process
For the past several years, Min Guo, an assistant professor at The Scripps Research Institute, has focused on the intricate actions of an ancient family of catalytic enzymes that play a key role in translation, the process ...
Nov 15, 2012
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Rare parasitic fungi could have anti-flammatory benefits
Scientists at The University of Nottingham have discovered that a rare parasitic fungus that lives on hibernating caterpillars in Tibet could have a role to play in anti-inflammatory drugs for conditions such as asthma.
Nov 14, 2012
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Viable and fertile fruit flies in the absence of histone H3.3
Histones—proteins that package DNA—affect cell function differently than previously assumed: the cell doesn't need the histone H3.3 to read genes. Molecular biologists from the University of Zurich demonstrate ...
Nov 13, 2012
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MicroRNAs in plants: Regulation of the regulator
MicroRNAs are essential regulators of the genetic program in multicellular organisms. Because of their potent effects, the production of these small regulators has itself to be tightly controlled. That is ...
Nov 08, 2012
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New portable device enables RNA detection from ultra-small sample in only 20 minutes
A new power-free microfluidic chip developed by researchers at the RIKEN Advanced Science Institute (ASI) enables detection of microRNA from extremely small sample volume in only 20 minutes. By drastically ...
Nov 07, 2012
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