Mapping the 3-D geometry of SARS-CoV-2's genome
The novel coronavirus uses structures within its RNA to infect cells. Scientists have now identified these configurations, generating the most comprehensive atlas to date of SARS-CoV-2's genome.
The novel coronavirus uses structures within its RNA to infect cells. Scientists have now identified these configurations, generating the most comprehensive atlas to date of SARS-CoV-2's genome.
Biotechnology
Sep 1, 2020
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37
Many viruses, including HIV and influenza A, mutate so quickly that identifying effective vaccines or treatments is like trying to hit a moving target. A better understanding of viral propagation and evolution in single cells ...
Biochemistry
Aug 20, 2020
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175
To fight viruses, cells can deploy defense enzymes that progressively destroy viral genome strands starting from one of the two strand ends. However, this degradation mechanism is not effective against epidemic viruses such ...
Molecular & Computational biology
Jul 30, 2020
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5
For the first time, scientists at the Morgridge Institute for Research have generated near atomic resolution images of a major viral protein complex responsible for replicating the RNA genome of a member of the positive-strand ...
Molecular & Computational biology
Jul 20, 2020
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241
Researchers from the Monash Biomedicine Discovery Institute (BDI) have revealed the structure of a protein complex that is essential for the poliovirus to replicate. The structure may be similar to those in other RNA viruses ...
Cell & Microbiology
Jun 19, 2020
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2
The quick, accurate detection of a virus on a wide scale is the key to combating infectious diseases such as COVID-19. A new viral diagnostic strategy using reactive polymer-grafted, double-stranded RNAs will serve as a pre-screening ...
Cell & Microbiology
Jun 2, 2020
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9
More than 70% of all viruses known to cause human disease, including the one that causes COVID-19, are RNA viruses. They invade the body by hijacking the internal machinery of cells. Yet little is known about how viral RNA ...
Cell & Microbiology
May 8, 2020
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88
In November of 2019—likely, even earlier—a tiny entity measuring just a few hundred billionths of a meter in diameter began to tear apart human society on a global scale. Within a few months, the relentless voyager known ...
Cell & Microbiology
Apr 28, 2020
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224
Jean and Peter Medawar wrote in 1977 that a virus is "simply a piece of bad news wrapped up in proteins." The 'bad news' in the SARS-CoV-2 case is the new coronavirus carries its mysterious genome in the form of a very long ...
Biotechnology
Apr 9, 2020
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631
All organisms have DNA, the genetic material that provides a blueprint for life. The long double-helix-shaped DNA molecules in the body's cells are first translated into RNA molecules and then translated into proteins that ...
Plants & Animals
Apr 9, 2020
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36