News tagged with rna splicing
Real-time monitoring of RNA splicing in living cells moves step closer with novel fluorescent probe
Numerous biological processes depend on molecules called lariat RNAs (LaRNAs). These lasso-shaped structures form in the cell during RNA splicing. During this process, transcribed RNA strands convert to messenger ...
May 24, 2012 |
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Research uncovers new exception to decades-old rule about RNA splicing
There are always exceptions to a rule, even one that has prevailed for more than three decades, as demonstrated by a Cold Spring Harbor Laboratory (CSHL) study on RNA splicing, a cellular editing process. The rule-flaunting ...
May 17, 2012 |
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The splice of life: Proteins cooperate to regulate gene splicing
Understanding how RNA binding proteins control the genetic splicing code is fundamental to human biology and disease – much like editing film can change a movie scene. Abnormal variations in splicing ...
Feb 16, 2012 |
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Temperature controls the genetic message
Alternative splicing, the mechanism enabling a gen to encode different proteins, according to the cell's needs, still holds many secrets. It has transformed the initial theory of one gen, one protein, but how it is controlled ...
Sep 16, 2011 |
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New mechanism in the regulation of human genes
Scientists at the Technical University of Munich and the Helmholtz Zentrum Muenchen and along with their colleagues from the European Molecular Biology Laboratory (EMBL) in Heidelberg and the Centre for Genomic Regulation ...
Jul 14, 2011 |
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Genetic mutation linked to lethal disease
Researchers have identified a genetic mutation found in the Ohio Amish population as the cause of a fatal developmental disease in fetuses and infants, according to research published in the April 8, 2011, issue of Science.
Apr 18, 2011 |
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Lasers, custom microscope show gene splicing process in real time
From neurosurgery to bar code readers, lasers have been used in a myriad of applications since they were first introduced in the late 1950's. Now, with the work being done in Jeff Gelles' Lab at Brandeis University, ...
Mar 10, 2011 |
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Engineered molecule changes itself to detect and attack diseased cells
(PhysOrg.com) -- Assistant Professor of Bioengineering Christina Smolke has engineered biological molecules that regulate a cell's behavior by adjusting their own forms and functions in response to the internal conditions ...
Nov 30, 2010 |
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Cancer-associated long non-coding RNA regulates pre-mRNA splicing
Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing - a critical step in the earliest stage of protein production. Their study appears in the ...
Sep 23, 2010 |
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Spying on a cellular director in the cutting room
Like a film director cutting out extraneous footage to create a blockbuster, the cellular machine called the spliceosome snips out unwanted stretches of genetic material and joins the remaining pieces to fashion a template ...
Mar 21, 2010 |
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Gladstone scientists identify role of key protein in ALS and frontotemporal dementia
Scientists at the Gladstone Institute of Neurological Disease (GIND) have identified the reason a key protein plays a major role in two neurodegenerative diseases. In the current edition of the Journal of Neuroscience, re ...
Medicine & Health / Neuroscience
Jan 12, 2010 |
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Possible help in fight against muscle-wasting disease (w/ Video)
(PhysOrg.com) -- A compound already used to treat pneumonia could become a new therapy for an inherited muscular wasting disease, according to researchers at the University of Oregon and the University of ...
Medicine & Health / Medical research
Nov 06, 2009 |
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Researchers identify drug candidate for treating spinal muscular atrophy
A chemical cousin of the common antibiotic tetracycline might be useful in treating spinal muscular atrophy (SMA), a currently incurable disease that is the leading genetic cause of death in infants. This is the finding of ...
Medicine & Health / Medical research
Nov 04, 2009 |
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Of yeast and men: Unraveling the molecular mechanisms of Friedreich's ataxia
Researchers in human genetics have long known that expansions of GAA repeats - resulting in this nucleotide triplet repeating hundreds or thousands of times - cause the most common hereditary neurological disorder known as ...
Jul 09, 2009 |
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Scientists discover master regulator of motor neuron firing
(PhysOrg.com) -- When the Human Genome Project was complete, DNA bowed out of the limelight and gave way to RNA as a major player in genetic regulation. Now, findings at Rockefeller University mirror this ...
Medicine & Health / Neuroscience
Mar 16, 2009 |
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