A technique can determine for the first time how frequently, and exactly where, a molecular event called "backtracking" occurs throughout the genetic material (genome) of any species, a new study shows.
Biotechnology
Feb 9, 2024
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286
Researchers at the University of Toronto have shown that an enzyme called RNA polymerase (Pol) II drives generation of the building blocks of ribosomes, the molecular machines that manufacture all proteins in cells based ...
Molecular & Computational biology
Jul 15, 2020
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309
(PhysOrg.com) -- The human genome contains some 3 billion base pairs that are tightly compacted into the nucleus of each cell. If a DNA strand were the thickness of a human hair, the entire human genome would be crammed into ...
Cell & Microbiology
Jan 17, 2012
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When egg and sperm combine, the new embryo bustles with activity. Its cells multiply so rapidly they largely ignore their DNA, other than to copy it and to read just a few essential genes. The embryonic cells mainly rely ...
Biotechnology
Aug 13, 2013
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RNA polymerase II (Pol II), a key enzyme in our gene expression, is responsible for transcribing DNA into messenger RNA. Errors in transcription can cause deleterious effect upon repeated translation of erroneous mRNA into ...
Cell & Microbiology
May 3, 2016
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(PhysOrg.com) -- The body's nanomachines that read our genes don't run as smoothly as previously thought, according to a new study by University of California, Berkeley, scientists.
Biochemistry
Jul 30, 2009
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Just like orchestra musicians waiting for their cue, RNA polymerase II molecules are poised at the start site of many developmentally controlled genes, waiting for the "Go!"- signal to read their part of the genomic symphony. ...
Cell & Microbiology
Jul 14, 2011
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Indiana University biologists have found that specific types of RNA polymerase enzymes, the molecular machines that convert DNA into RNA, can differ in function based on variation in the parts -- in this case protein subunits ...
Biotechnology
Mar 1, 2012
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Every cell in your body carries the same genetic instructions, and yet cells don't accidentally turn into bone inside your heart, and teeth don't grow in your brain. This is thanks to systems of precise control over the expression ...
Biochemistry
Sep 15, 2015
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116
(Phys.org) -- When genetic information is read from the genetic blueprint DNA, RNA polymerase II translates it into RNA molecules. The C-terminal domain, abbreviated as CTD, is an important area of the polymerase molecule. ...
Biotechnology
May 21, 2012
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