Unfolding the blindness proteins through fly eyes

Every 6 minutes someone is told they're going blind. One of the major causes of human blindness is a disease called Retinitis Pigmentosa (RP), which causes progressive degeneration of the retina and vision loss. Approximately ...

A rice fish model of a rare metabolic disorder

Human cells are kept healthy by the activity of millions of proteins. These proteins are modified in different ways, such as by adding sugar molecules to them, which can be crucial for them to function properly. Given this ...

A simple twist of cell fate

How do a couple of universally expressed proteins in stem cells and developing embryos influence an individual cell's ultimate fate—whether it ultimately becomes, for example, a retinal cell, a heart muscle cell, or a stomach ...

A timekeeper for siesta

Circadian clocks must be flexible and they must be able to adapt to varying environmental conditions. Otherwise, it would be impossible for living beings to change their patterns of activity when the days get shorter again ...

Novel mechanism of inheritance detected

Non-Mendelian, oligogenic inheritance could be an unrecognized and important element for occurrence of hereditary retinal degenerations (HRDs, comprising retinitis pigmentosa) which are caused by ultra-rare mutations and ...

Researchers develop increasingly complex mini-brains

Scientists of the D'Or Institute for Research and Education have improved the initial steps of a standard protocol and produced organoids displaying regionalized brain structures, including retinal pigmented cells. Their ...

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