Researchers discover that protein switches functions to regulate DNA replication
One protein. One mechanism of action. Two biologically opposite effects.
Biotechnology
Jul 23, 2021
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News tagged with replication fork
With tiny technological tweezers, researchers uncover new aspects of cell division
The body's cells are constantly dividing—which, somewhat counterintuitively, means that they're constantly multiplying. Because when a cell divides it doesn't split into two useless halves, but rather into two fully functional ...
Cell & Microbiology
Aug 8, 2019
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13
Unveiling the mechanism protecting replicated DNA from degradation
Researchers from Tokyo Metropolitan University and the FIRC Institute of Molecular Oncology (IFOM) in Italy have succeeded in depleting AND-1, a key protein for DNA replication, by using a recently developed conditional protein ...
Cell & Microbiology
Oct 1, 2018
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Detangling DNA replication
DNA is a lengthy molecule—approximately 1,000-fold longer than the cell in which it resides—so it can't be jammed in haphazardly. Rather, it must be neatly organized so proteins involved in critical processes can access ...
Cell & Microbiology
Sep 18, 2018
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Many forks make light work
New insights into the control of DNA replication and cell division in Corynebacterium glutamicum, a biotechnologically important microorganism, could help to optimize the industrial production of amino acids.
Cell & Microbiology
Jun 7, 2017
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Eukaryote process of programmed fork arrest determined
A research collaboration between the Medical University of South Carolina, the Institute of Human Genetics in France, and Howard Hughes Medical Institute at Rockefeller University has revealed the means by which cells accomplish ...
Cell & Microbiology
Jun 14, 2016
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14
Enzyme with high potential for new cancer treatment identified
A team of researchers from the Biology department at the TU Darmstadt has identified an enzyme that separates DNA replication from repair. This discovery could be of tremendous significance in the treatment of tumours. The ...
Cell & Microbiology
Jun 3, 2016
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High fidelity: Researcher finds keys to genome integrity
Maintaining the stability and the correct sequence of our genetic information is vital to the accurate transmission of our genetic code. However, in the course of replicating, our DNA frequently runs into roadblocks, arising ...
Cell & Microbiology
Apr 14, 2015
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34
Blocking a fork in the road to DNA replication
A team of Whitehead Institute scientists has discovered the surprising manner in which an enigmatic protein known as SUUR acts to control gene copy number during DNA replication. It's a finding that could shed new light on ...
Cell & Microbiology
Oct 30, 2014
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Rockefeller scientists first to reconstitute the DNA 'replication fork'
When a cell divides, it must first make a copy of its DNA, a fundamental step in the life cycle of cells that occurs billions of times a day in the human body. While scientists have had an idea of the molecular tools that ...
Cell & Microbiology
Jul 9, 2014
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