Malignant cells adopt a different pathway for genome duplication

Genomes must be replicated in two copies during cell division. This process occurs at structures called 'replication forks', which are equipped with enzymes and move along the separated DNA strands. In tumour cells, the replication ...

Tumors elude anti-cancer drugs through 'fork reversal' repair

In research recently published in Nature Structural & Molecular Biology, Alessandro Vindigni, Ph.D., associate professor of biochemistry and molecular biology at Saint Louis University, discovered how cancer cells respond ...

Dual systems key to keeping chromosomes intact

USC scientists have discovered how two different structural apparatuses collaborate to protect repetitive DNA when it is at its most vulnerable – while it is being unzipped for replication.

Handle with care: Telomeres resemble DNA fragile sites

(PhysOrg.com) -- Telomeres, the repetitive sequences of DNA at the ends of linear chromosomes, have an important function: They protect vulnerable chromosome ends from molecular attack. Researchers at Rockefeller University ...

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