News tagged with replication fork
Study reveals new role for RNA interference during chromosomal replication
At the same time that a cell's DNA gets duplicated, a third of it gets super-compacted into repetitive clumps called heterochromatin. This dense packing serves to repress or "silence" the DNA sequences within -- which could ...
Oct 16, 2011 |
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Handle with care: Telomeres resemble DNA fragile sites
(PhysOrg.com) -- Telomeres, the repetitive sequences of DNA at the ends of linear chromosomes, have an important function: They protect vulnerable chromosome ends from molecular attack. Researchers at Rockefeller ...
Jul 10, 2009 |
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Search results for replication fork
Study suggests enzyme crucial to DNA replication may provide potent anti-cancer drug target
(PhysOrg.com) -- An enzyme essential for DNA replication and repair in humans works in a way that might be exploited as anti-cancer therapy, say researchers at The Scripps Research Institute and Lawrence Berkeley ...
Apr 14, 2011 |
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New molecule identified in DNA damage response
(PhysOrg.com) -- Evolution places the highest premium on reproduction, natural selection’s only standard for biological success. In the case of replicating cells, life spares no expense to ensure that the ...
Dec 08, 2009 |
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Chemotherapy resistance: Checkpoint protein provides armor against cancer drugs
Cell cycle checkpoints act like molecular tripwires for damaged cells, forcing them to pause and take stock. Leave the tripwire in place for too long, though, and cancer cells will press on regardless, making ...
Aug 27, 2009 |
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Of yeast and men: Unraveling the molecular mechanisms of Friedreich's ataxia
Researchers in human genetics have long known that expansions of GAA repeats - resulting in this nucleotide triplet repeating hundreds or thousands of times - cause the most common hereditary neurological disorder known as ...
Jul 09, 2009 |
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DNA template could explain evolutionary shifts
Rearrangements of all sizes in genomes, genes and exons can result from a glitch in DNA copying that occurs when the process stalls at a critical point and then shifts to a different genetic template, duplicating and even ...
Jun 21, 2009 |
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First glimpse of a key DNA repair protein at work
Repairing breaks in the two strands of the DNA double helix is critical for avoiding cancer. In humans and other organisms, a molecular machine called the MRN complex is responsible for finding and signaling ...
Biology /
Oct 03, 2008 |
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Common molecule notifies immune system of prostate cancer
In experiments with mice, researchers have found that the body’s immune system can use a surprisingly common molecule to recognize prostate tumors. The molecule comes from a protein found in all cells of the body; however, ...
Jan 10, 2008 |
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Copy number variation may stem from replication misstep
Genome rearrangements, resulting in variations in the numbers of copies of genes, occur when the cellular process that copies DNA during cell division stalls and then switches to a different genetic “template,” said researchers ...
Dec 27, 2007 |
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Tiny tweezers and yeast help researchers show how cancer drug works
The annoying bulges of an over-wound telephone cord that shorten its reach and limit a caller’s motion help to explain why drugs called camptothecins are so effective in killing cancer cells, according to investigators at ...
Nanotechnology / Bio & Medicine
Jul 09, 2007 |
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Researchers solve mystery of how DNA strands separate
Cornell researchers have answered a fundamental question about how two strands of DNA, known as a double helix, separate to start a process called replication, in which genes copy themselves.
Biology /
Jul 03, 2007 |
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List of search results for replication fork
