Researchers create bioluminescent tag to detect DNA break repair

A new bioluminescent reporter that tracks DNA double stranded break (DSB) repair in cells has been developed by researchers from Massachusetts General Hospital (MGH) and the Academia Sinica in Taiwan. The international team's ...

Probing DNA damage repair

Cells missing the protein HMCES are hypersensitive to DNA-damaging agents that cause a common type of DNA lesion—an "abasic" site. But the agents also generate other types of lesions associated with mutations and cell lethality, ...

Real-time observation of enzymatic processes on DNA

DNA damage in general and DNA strand breaks in particular occur every day in all cells of the human body. This is due to internal influences such as free radicals, which are produced during inflammatory processes and cellular ...

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