A new understanding of insulin resistance and the action of diabetes drugs such as Avandia and Actos could pave the way for improved medications that are more selective and safer, say scientists from Dana-Farber Cancer Institute ...
Jul 21, 2010
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In Alzheimer's disease, brain neurons become clogged with tangled proteins. Scientists suspect these tangles arise partly due to malfunctions in a little-known regulatory system within cells. Now, researchers have dramatically ...
Apr 16, 2012
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In exploring how proteins interact with crucial DNA sequences to regulate gene activity, researchers have shed light on key biological events that may eventually be manipulated to provide new disease treatments.
Jun 07, 2012
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(Phys.org)—It's not just a few key genes and proteins that cycle on and off in humans in a 24-hour circadian pattern as the sun rises and falls. Thousands of genes in organs throughout the body show predictable daily fluctuations, ...
Sep 03, 2012
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Recently biologists at the University of Massachusetts Amherst led by Wei-lih Lee have identified a new molecular player in asymmetric cell division, a regulatory protein named She1 whose role in chromosome- ...
Nov 08, 2012
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Over the past several years, Rong Li, Ph.D., at the Stowers Institute for Medical Research has been making crucial discoveries about the development of cell polarity—the process by which one side of a cell ...
Jan 22, 2013
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Our genome is a patchwork of neighborhoods that couldn't be more different: Some areas are hustling and bustling with gene activity, while others are sparsely populated and in perpetual lock-down. Breaking ...
May 14, 2009
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Proteins are the executive agents that carry out all processes in a cell. Their activity is controlled and modified with the help of small chemical tags that can be dynamically added to and removed from the protein. 25 years ...
May 29, 2009
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With the information explosion, it's remarkable that so little is known about the interactions that proteins have with each other and the protective membrane that surrounds a cell. These interactive, so-called membrane proteins ...
Aug 06, 2009
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Understanding the incredibly speedy atomic mechanisms at work when a protein transitions from one shape to another has been an elusive scientific goal for years, but an essential one for elucidating the full ...
Dec 10, 2009
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In a study using the Drosophila, researchers at the IRB Barcelona, Spain, have discovered that the microRNA machinery controls the levels of Myc through the molecule Mei-P26, thereby conferring microRNAs unexpected ...
Apr 20, 2010
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(PhysOrg.com) -- Researchers at the University of Illinois at Chicago have discovered a signaling mechanism in the bacterial ribosome that detects proteins that activate genes for antibiotic resistance.
Feb 23, 2011
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Not all cholesterol is bad. Every cell requires it for growth – they either have to get cholesterol somewhere or they die. In a new study published April 6 in the journal Cell Metabolism, researchers from Sanford-Burnham Medica ...
Apr 05, 2011
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During the development of an embryo, a large number of different, specialised cell-types arise from the fertilised egg. The genetic information is identical in all cells of an organism. Different properties ...
May 02, 2011
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By knocking out a key regulatory protein, scientists at the University of California, San Diego School of Medicine and the Ecole Polytechnique Federale de Lausanne (EPFL) in Switzerland dramatically boosted ...
Nov 10, 2011
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