Related topics: receptors · cancer cells · cells

New possible target for treating major common diseases

There is a large, untapped potential for developing drugs against cancer, fibrosis and cardiovascular diseases by targeting a family of receptors known as Frizzleds, researchers at Karolinska Institutet in Sweden believe. ...

Cryo-EM reveals structure and mechanism of the 5-HT3 receptor

In November 2017, a Titan Krios cryo-electron microscope (cryo-EM) was inaugurated at the ESRF, the European Synchrotron, France. Data collected on this cryo-EM features in a Nature publication describing the activation cycle ...

Scientists alter membrane proteins to make them easier to study

About 30 percent of the proteins encoded by the human genome are membrane proteins—proteins that span the cell membrane so they can facilitate communication between cells and their environment. These molecules are critical ...

CryoEM study captures opioid signaling in the act

Opioid drugs like morphine and fentanyl are a mainstay of modern pain medicine. But they also cause constipation, are highly addictive, and can lead to fatal respiratory failure if taken at too high a dose. Scientists have ...

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