Researchers have launched an ultra-large virtual docking library expected to grow to more than 1 billion molecules by next year. It will expand by 1000-fold the number of such "make-on-demand" compounds readily available ...
Biochemistry
Feb 6, 2019
0
59
There is a large, untapped potential for developing drugs against cancer, fibrosis and cardiovascular diseases by targeting a family of receptors known as Frizzleds, researchers at Karolinska Institutet in Sweden believe. ...
Biochemistry
Dec 4, 2018
0
71
If certain signaling cascades are misregulated, diseases like cancer, obesity and diabetes may occur. A mechanism recently discovered by scientists at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) in ...
Cell & Microbiology
Aug 15, 2018
0
2
Alcohol use disorders can have devastating effects on a person's health, relationships and finances. Yet for some, the feeling they get when taking a drink temporarily outweighs these other concerns. Now, researchers have ...
Other
Aug 8, 2018
0
2
Opioid drugs like morphine and fentanyl are a mainstay of modern pain medicine. But they also cause constipation, are highly addictive, and can lead to fatal respiratory failure if taken at too high a dose. Scientists have ...
Biochemistry
Jun 22, 2018
0
74
Scientists at Heptares Therapeutics have published the first high-resolution X-ray crystal structure of the complement C5a receptor (a G protein-coupled receptor, GPCR) binding a small molecule allosteric antagonist.
Biochemistry
Jan 4, 2018
0
7
With the heightened concerns over the dangerous side effects of the once-popular antidiabetic drug Avandia, researchers at The Scripps Research Institute (TSRI) in Jupiter, Florida, are working to understand how small molecules, ...
Biochemistry
Sep 30, 2017
0
93
A discovery by Indiana University researchers could advance the long-term storage of nuclear waste, an increasingly burdensome and costly task for the public and private agencies that protect people from these harmful chemicals.
Materials Science
Sep 14, 2017
2
94
As senses go, there's nothing so immediate and concrete as our sense of touch. So it may come as a surprise that, on the molecular level, our sense of touch is still poorly understood.
Cell & Microbiology
Jul 4, 2017
0
266
Researchers from the University of Bristol have found a way to mimic the way cells in living organisms 'talk' to the world around them by creating a world-first synthetic receptor which can respond to chemical signals just ...
Biochemistry
Mar 6, 2017
0
25
