G-protein coupled receptors (GPCRs) are the "inbox" of environmental messages in mammalian cells. Because of their central role in signaling pathways, mutations resulting in abnormal GPCR functions cause a wide variety of ...
Molecular & Computational biology
Apr 15, 2019
0
7
Scientists at Harvard Medical School and the Dana-Farber Cancer Institute have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within cancer cells.
Biochemistry
Apr 4, 2019
0
7
Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and ...
Biochemistry
Mar 20, 2019
0
186
Lysophospholipids (LysoPLs) are potent cellular signaling biomolecules that also maintain the structure, shape and fluidity of cell membranes.
Oncology & Cancer
Feb 18, 2019
0
3
Cellular signaling pathways involved in everything from the proliferation of fatty tissue to the death of neurons in the brain are tightly regulated by "cascades" of sequentially activated enzymes, MAP kinases. These enzymes ...
Cell & Microbiology
Jan 21, 2019
0
4
Scientists from VIB and Ghent University under the guidance of Prof. Dr. Jenny Russinova have uncovered a novel mechanism in plants that controls an important decision step in stomatal lineage to divide asymmetrically or ...
Plants & Animals
Nov 15, 2018
0
15
Researchers at the University of Eastern Finland have developed novel antibacterial compounds, focusing on the role of LsrK kinase. LsrK kinase is a protein involved in bacterial communication. In a new study published in ...
Biochemistry
Nov 1, 2018
0
73
The gut is lined by cells containing brush borders, which are composed of arrays of microvillar protrusions that help in nutrient absorption and provide a barrier against pathogens and toxins. Microbes such as E. coli can ...
Cell & Microbiology
Sep 24, 2018
0
4
University of Leicester researchers have shed new light on how bacteria sense nutrients in their environment—which could provide important knowledge in the development of drugs and antibiotics to combat a range of diseases ...
Cell & Microbiology
Aug 3, 2018
0
28
The post-translational addition of phosphate groups to serine, threonine and tyrosine residues is a fundamental strategy for regulating protein activities in eukaryotes. Eukaryotic protein kinases—the enzymes that catalyze ...
Cell & Microbiology
Jul 17, 2018
0
6
