News tagged with protein aggregates
New discoveries in cell aging
A group of researchers led by the Institute of Biotechnology and Biomedicine (IBB) and Universitat Autònoma de Barcelona (UAB) have achieved to quantify with precision the effect of protein aggregation on cell aging ...
Jan 23, 2012 |
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How old yeast cells send off their daughter cells without the baggage of old age
The accumulation of damaged protein is a hallmark of aging that not even the humble baker's yeast can escape. Yet, aged yeast cells spawn off youthful daughter cells without any of the telltale protein clumps. ...
Nov 23, 2011 |
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Good housekeeping maintains a healthy liver
Differences in the levels of two key metabolic enzymes may explain why some people are more susceptible to liver damage, according to a study in the October 17 issue of the Journal of Cell Biology.
Oct 17, 2011 |
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Cellular stress can induce yeast to promote prion formation
It's a chicken and egg question. Where do the infectious protein particles called prions come from? Essentially clumps of misfolded proteins, prions cause neurodegenerative disorders, such as mad cow/Creutzfeld-Jakob disease, ...
Jul 23, 2011 |
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A chaperone system guides tail-anchored membrane proteins to their destined membrane
Newly synthesized proteins can only fold into their correct three dimensional structure thanks to chaperones. In case of membrane proteins chaperones do not only prevent their aggregation, but also escort ...
Jul 05, 2011 |
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Scientists develop algorithm to understand certain human diseases
(Medical Xpress) -- Patricia Clark, the Rev. John Cardinal O’Hara, C.S.C. Associate Professor of Chemistry and Biochemistry at the University of Notre Dame, and Bonnie Berger, professor of applied mathematics at the ...
Jun 16, 2011 |
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Clue to cause of motor neurone disease revealed in new genetic study
Researchers have discovered a fifth genetic mutation associated with typical motor neurone disease, or amyotrophic lateral sclerosis, that has a similar pathological effect to certain genetic mutations revealed in earlier ...
Apr 05, 2010 |
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Researchers Suggest New Approach in Development Efforts for Parkinson’s Therapeutics
(PhysOrg.com) -- Researchers outline today a new approach in the potential development of drugs to counter a cellular defect that triggers Parkinson’s and other diseases.
Jul 14, 2009 |
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Researchers surprised by similar structures in Sanfilippo syndrome and Alzheimer's disease
Researchers seeking to understand the causes of a rare genetic lysosomal storage disease, Sanfilippo syndrome type B, were surprised to find protein aggregates, known as neurofibrillary tangles, that are usually ...
Medicine & Health / Neuroscience
May 04, 2009 |
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Survival mode that protects cells when oxygen is low also slows aging (w/Video)
A biochemical pathway that helps keep cells alive when oxygen is low also plays a role in longevity and resistance against some diseases of old age, according to a report to be published April 16 in the journal ...
Medicine & Health / Medical research
Apr 16, 2009 |
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Researchers describe molecular 'two-step' leading to protein clumps of Huntington's disease
In a paper published in the early online version of Nature Structural and Molecular Biology, researchers at the University of Pittsburgh School of Medicine deconstruct the first steps in an intricate molecular dance that m ...
Mar 08, 2009 |
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New Pathway is a Common Thread in Age-Related Neurodegenerative Diseases
How are neurodegenerative diseases such as Alzheimer's initiated, and why is age the major risk factor? A recent study of a protein called MOCA (Modifier of Cell Adhesion), carried out at the Salk Institute ...
Medicine & Health / Medical research
Jan 29, 2009 |
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