News tagged with proteasome
Related topics: protein
Immunoproteasome crystal structure determined
Like a shredder, the immunoproteasome cuts down proteins into peptides that are subsequently presented on the cellular surface. The immune system can distinguish between self and nonself peptides and selectively ...
Feb 16, 2012 |
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How cells dispose of their waste
German researchers reveal the structure of cellular protein degradation machinery.
Jan 23, 2012 |
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Protein-devouring enzyme complex uses two different mechanisms to determine which targets to destroy
The proteasome is the garbage-disposal system of the cell, enzymatically clearing away unwanted proteins. Since this requires the recognition of individual targets within the crowded cellular environment, ...
Apr 28, 2011 |
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Researchers identify potential new drug for neurodegenerative disease
Scientists have discovered a small molecule that helps human cells get rid of the misfolded, disfigured proteins implicated in Alzheimer's disease and other neurodegenerative ailments. This potential drug could have applications ...
Medicine & Health / Medical research
Sep 08, 2010 |
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Harmful amyloid interferes with trash pickup for cells in Alzheimer's disease
Chemists at the University of California, San Diego, have identified how a protein that accumulates in the brains of people with Alzheimer's disease interferes with the ability of cells to get rid of debris. ...
Medicine & Health / Neuroscience
Sep 08, 2010 |
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When Good Cells Go Bad: Scientist Researchers Cellular Structure
(PhysOrg.com) -- While some biological research may not directly provide cures for major diseases, it can provide the scientific basis for research that might. Work by Kansas State University's Jeroen Roelofs is one such ...
Medicine & Health / Medical research
Jul 13, 2010 |
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New Details of Tuberculosis Protein-Cleaving Machinery Revealed
(PhysOrg.com) -- Scientists looking for new ways to fight tuberculosis (TB) have their sights set on a structure essential to the bacterium's survival. Disabling this structure could kill the microbes in the ...
Medicine & Health / Medical research
May 11, 2010 |
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IKK may act as both inhibitor and promoter of Huntington's disease
The kinase IKK phosphorylates the protein mutated in Huntington's disease to promote its removal and neuron survival, but IKK may be a double-edged sword that increases neurotoxicity in later stages of the disease. The study, ...
Dec 21, 2009 |
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Approved Lymphoma Drug Shows Promise in Early Tests Against Bone Cancer
(PhysOrg.com) -- A drug already approved for the treatment of lymphoma may also slow the growth of the most deadly bone cancer in children and teens, according to an early-stage study published online today ...
Nov 05, 2009 |
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KEAP1 Keeps major cancer-promoting protein at bay
A tumor-suppressing protein snatches up an important cancer-promoting enzyme and tags it with molecules that condemn it to destruction, a research team led by scientists at The University of Texas M. D. Anderson ...
Oct 09, 2009 |
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Researchers identify new, cancer-causing role for protein
The mainstay immune system protein TRAF6 plays an unexpected, key role activating a cell signaling molecule that in mutant form is associated with cancer growth, researchers at The University of Texas M. D. ...
Aug 27, 2009 |
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Researchers Find Tools Needed To Build a Cellular Shredder
(PhysOrg.com) -- Yale University researchers have discovered a set of cellular chaperones needed to assemble a proteasome, the cellular workhorse that recycles proteins and is crucial for the existence of all eukaryotic cells.
May 28, 2009 |
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