News tagged with plx4032
Trial of new treatment for advanced melanoma shows rapid shrinking of tumors
Berlin, Germany: Researchers have made significant advances in the treatment of metastatic malignant melanoma - one of the most difficult cancers to treat successfully once it has started to spread - according to a study ...
Sep 23, 2009 |
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Killing drug-resistant melanoma requires combination therapy
This past summer saw a revolution in melanoma therapy. Patients whose melanoma lesions contain a mutation in the BRAF gene were successfully treated with a BRAF-specific inhibitor, PLX4032. Reports of the ...
Dec 13, 2010 |
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Researchers discover drug resistance mechanisms in most common form of melanoma
Researchers with UCLA's Jonsson Comprehensive Cancer Center have found that melanoma patients whose cancers are caused by mutation of the BRAF gene become resistant to a promising targeted treatment through another genetic ...
Nov 24, 2010 |
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New drug for metastatic melanoma shows promising results in clinical trial
A clinical trial of a promising new experimental therapy for metastatic melanoma has shown positive results, including tumor shrinkage in the majority of patients. The positive results support previously reported positive ...
Nov 11, 2010 |
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Highlight: Scientific breakdown of cancer reveals promising results
The chemical structure of the melanoma-shrinking drug PLX4032 is revealed in a new Nature paper that describes the drug’s discovery, development and functioning.
Sep 09, 2010 |
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Targeted drug leads to regression of metastatic melanoma with mutated BRAF gene
Use of an experimental targeted drug to treat metastatic melanoma tumors with a specific genetic signature was successful in more than 80 percent of patients in a phase 1 clinical trial. Results of the trial of PLX4032, ...
Aug 25, 2010 |
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BRAF inhibitor shows promising preclinical activity against melanoma
Preclinical findings recently published in Cancer Research, a journal of the American Association for Cancer Research, showed RG7204 (PLX4032) inhibited proliferation of tumor cell lines that expressed V600E-BRAF, a muta ...
Jun 15, 2010 |
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