Protein structure unlocks one mystery of multi-drug tolerance
The structures of key bacterial proteins have revealed one of the biochemical secrets that enables bacteria to outwit antibiotics.
Sep 26, 2012
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Sep 26, 2012
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Researcher investigates how cells tune in to important information
(Phys.org)—Every minute of its existence, a living cell must assess and analyze myriad bits of information—everything from the temperature of its environment to the chemical makeup of its surroundings. Sometimes, these ...
Jan 25, 2013
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Molecular spectroscopy tracks living mammalian cells in real time as they differentiate
Knowing how a living cell works means knowing how the chemistry inside the cell changes as the functions of the cell change. Protein phosphorylation, for example, controls everything from cell proliferation ...
Apr 30, 2012
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Different evolutionary paths lead plants and animals to the same crossroads
In analyzing the molecular sensor for the plant growth hormone brassinolide, researchers at the Salk Institute for Biological Studies discovered that although plants took an evolutionary path different from ...
Jan 31, 2011
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Researchers uncover mechanism that regulates human pluripotent stem cell metabolism
Human pluripotent stem cells, which can develop into any cell type in the body, rely heavily on glycolysis, or sugar fermentation, to drive their metabolic activities.
Nov 15, 2011
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Key enzyme discovered to be master regulator in protein-protein reactions
Protein phosphorylation is a process by which proteins are flipped from one activation state to another. It is a crucial function for most living beings, since phosphorylation controls nearly every cellular ...
Mar 24, 2010
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Proteomics identifies targets of ionizing radiation in a human skin model
(Phys.org) -- How better to find out what effect ionizing radiation has on human skin than by using the real thing? Researchers at Pacific Northwest National Laboratory did that by performing a quantitative ...
Apr 24, 2012
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What makes stem cells tick?
Investigators at the Burnham Institute for Medical Research (Burnham) and The Scripps Research Institute (TSRI) have made the first comparative, large-scale phosphoproteomic analysis of human embryonic stem cells (hESCs) ...
Aug 06, 2009
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Cancers' sweet tooth may be weakness
The pedal-to-the-metal signals driving the growth of several types of cancer cells lead to a common switch governing the use of glucose, researchers at Winship Cancer Institute of Emory University have discovered.
Nov 18, 2009
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Scientists show protein-making machinery can switch gears with a small structural change process
For the past several years, Min Guo, an assistant professor at The Scripps Research Institute, has focused on the intricate actions of an ancient family of catalytic enzymes that play a key role in translation, the process ...
Nov 15, 2012
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Free radicals maybe good for you
Fear of free radicals may be exaggerated, according to scientists from Karolinska Institutet. A new study, published in The Journal of Physiology, shows that free radicals act as signal substances that cause the heart to ...
Feb 28, 2011
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Parkinson's disease may be caused by microtubule, rather than mitochondrial complex I, dysfunction
Patients with Parkinson's disease (PD) suffer a specific loss of dopaminergic neurons from the midbrain region that controls motor function. The exact mechanism of this selective neurodegeneration is unclear, ...
Mar 07, 2011
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New insights for a therapeutic approach in glioblastoma
(PhysOrg.com) -- Scientists from the Friedrich Miescher Institute for Biomedical Research have identified a new and important molecular player in glioblastoma. The amount of the MNK1 kinase is not only dramatically ...
Mar 18, 2011
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Purdue startup hopes to change the way we test cancer drugs
A Purdue University scientist's nanopolymer would make it easier and cheaper for drug developers to test the effectiveness of a widely used class of cancer inhibitors.
Mar 16, 2011
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DNA 'molecular scissors' discovered
(PhysOrg.com) -- Scientists at the University of Dundee have discovered a protein that acts as a 'molecular scissors' to repair damaged DNA in our cells, a finding which could have major implications for cancer treatments.
Jul 09, 2010
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