News tagged with peptide receptor
Immunoproteasome crystal structure determined
Like a shredder, the immunoproteasome cuts down proteins into peptides that are subsequently presented on the cellular surface. The immune system can distinguish between self and nonself peptides and selectively ...
Feb 16, 2012 |
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Researchers block morphine's itchy side effect
Itching is one of the most prevalent side effects of powerful, pain-killing drugs like morphine, oxycodone and other opioids. The opiate-associated itch is so common that even women who get epidurals for labor ...
Oct 13, 2011 |
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New peptide could be effective treatment for triple negative breast cancer
A new peptide developed by researchers in Temple University's College of Science and Technology has demonstrated efficacy against triple negative breast cancer.
Feb 28, 2011 |
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Neurological protein may hold the key to new treatments for depression
Neuroscientists at the Centre for Addiction and Mental Health (CAMH) have developed a protein peptide that may be a novel type of highly targeted treatment for depression with a low side-effect profile. Depression affects ...
Medicine & Health / Neuroscience
Nov 29, 2010 |
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Understanding the APJ Receptor Binding Site
(PhysOrg.com) -- Apelin is a recently discovered peptide that binds to the apelin (or APJ) G-protein-coupled receptor. Apelin-13 (NH2-QRPRLSHKGPMPF-COOH), one of several cleavage products of the proprotein ...
Jun 01, 2010 |
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New strategy develops two prototype drugs against cancer, retinal diseases
A comprehensive drug development strategy that starts with extensive screening of potential targeting agents and then narrows down to a small-molecule prototype has yielded two potential drugs that block cancer-promoting ...
Medicine & Health / Medical research
Feb 25, 2010 |
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Blocking signal molecule can prevent growth of large intestine and colon cancer
By seeing what substances and molecules affect the development of our diseases, we can develop drugs that prevent or cure diseases. In her dissertation at Kalmar University in Sweden, Ann Novotny has found that the signal ...
Sep 23, 2009 |
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Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells
Pancreatic cancer is a devastating disease with poor prognosis. This warrants the development of novel therapies including gene therapy. However, clinical studies have demonstrated poor efficacy of adenoviral gene therapy ...
Jun 23, 2009 |
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How to get obese mice moving -- and cure their diabetes
Mice lacking the fat hormone leptin or the ability to respond to it become morbidly obese and severely diabetic—not to mention downright sluggish. Now, a new study in the June Cell Metabolism shows that b ...
Jun 02, 2009 |
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Sniffing Out the Physical Condition of Conspecifics
To date, it has been unknown exactly how mammals are capable of sniffing out whether a conspecific is ill. The biologists Prof. Marc Spehr and Daniela Flügge are following a good lead. They have discovered ...
May 07, 2009 |
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