People with chronic pain are often dependent on drugs from the class of opioids with sometimes considerable side effects. Accordingly, in recent years the search for safer alternatives has been the focus of new drug discovery.
Biochemistry
Dec 6, 2023
0
20
Depression, obesity or chronic pain—all of these disorders can be triggered or promoted by stress. In two publications, researchers at TU Darmstadt show new ways of treating stress-related diseases.
Biochemistry
Nov 10, 2023
0
53
In the continuing effort to improve upon opioid pain relievers, American and Chinese scientists used cryoEM technology to solve the detailed structures of the entire family of opioid receptors bound to their naturally occurring ...
Molecular & Computational biology
Jan 12, 2023
0
24
Pain, especially chronic pain, is a common neurological phenomenon. The most common chronic pain conditions include low back pain, arthritis pain, migraine and cancer pain—all of which seriously affect people's physical ...
Biochemistry
Nov 16, 2022
0
94
New substances that activate adrenalin receptors instead of opioid receptors have a similar pain relieving effect to opiates, but without the negative aspects such as respiratory depression and addiction.
Biochemistry
Oct 4, 2022
0
33
Molecules in tarantula venom could be used as an alternative to opioid pain killers for people seeking chronic pain relief.
Biochemistry
Apr 14, 2020
0
6380
Abnormal levels of stress hormones such as adrenaline and cortisol are linked to a variety of mental health disorders, including depression and posttraumatic stress disorder (PTSD). MIT researchers have now devised a way ...
Bio & Medicine
Apr 13, 2020
0
1229
An international team of researchers has used nanoparticles to deliver a drug—one that previously failed in clinical trials for pain—into specific compartments of nerve cells, dramatically increasing its ability to treat ...
Bio & Medicine
Nov 4, 2019
2
1095
Conotoxins are bioactive peptides found in the venom that marine cone snails produce for prey capture and defense. They are used as pharmacological tools to study pain signalling and have the potential to become a new class ...
Biochemistry
Nov 4, 2019
0
11
The Arizona bark scorpion is the most venomous scorpion in North America. It possesses venom that causes serious pain in humans and can kill a child if anti-venom is not administered quickly.
Plants & Animals
Aug 30, 2017
0
525
