News tagged with p53
Scientists unlock key to cancer cell death mystery
An international team of scientists has announced a new advance in the ability to target and destroy certain cancer cells.
Mar 26, 2012 |
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Researchers pinpoint a new enemy for tumor-suppressor p53
Researchers at The University of Texas M. D. Anderson Cancer Center have identified a protein that marks the tumor suppressor p53 for destruction, providing a potential new avenue for restoring p53 in cancer ...
Jun 26, 2009 |
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Novel compound selectively kills cancer cells
A cancer cell may seem out of control, growing wildly and breaking all the rules of orderly cell life and death. But amid the seeming chaos there is a balance between a cancer cell's revved-up metabolism and skyrocketing ...
Jul 13, 2011 |
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Study shows that some malignant tumors can be shut down after all
Oncologists have had their hands tied because more than half of all human cancers have mutations that disable a protein called p53. As a critical anti-cancer watchdog, p53 masterminds several cancer-fighting operations within ...
Nov 09, 2009 |
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Chromosome's Guardians Susceptible to UV Radiation, Scientists Find
(PhysOrg.com) -- The molecular caps at the ends of chromosomes that protect humans against cancer and premature cellular aging show a surprising inability to protect themselves against ultraviolet radiation, ...
Apr 30, 2010 |
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MicroRNA to combat cancer
(PhysOrg.com) -- Researchers from the Queensland Institute of Medical Research, the Garvan Institute of Medical Research and the University of California-San Francisco have found a new way to kill cancer cells, opening the ...
Sep 28, 2010 |
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Newly discovered gene plays vital role in cancer
(PhysOrg.com) -- Gene p53 protects against cancer and is usually described as the most important gene in cancer research. However, scientists at the Swedish medical university Karolinska Institutet have now shown that a previously ...
Feb 27, 2009 |
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Scientists identify natural anti-cancer defenses
Canadian researchers have discovered a novel molecular mechanism that prevents cancer. In the December 11 edition of the prestigious journal Molecular Cell, scientists from the Université de Montréal and th ...
Dec 11, 2009 |
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Why cancer drugs lose their power: Platinum-based cancer drugs destroy tumor cells by binding to DNA strands
(PhysOrg.com) -- For 30 years, the chemotherapy drug cisplatin has been one of doctors' first lines of defense against tumors, especially those of the lung, ovary and testes. While cisplatin is often effective ...
Apr 14, 2010 |
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Researchers identify potential molecular target to prevent growth of cancer cells
Researchers have shown for the first time that the protein fortilin promotes growth of cancer cells by binding to and rendering inert protein p53, a known tumor suppressor. This finding by researchers at the University of ...
Sep 16, 2011 |
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Toward new drugs that turn genes on and off
Scientists in Michigan and California are reporting an advance toward development of a new generation of drugs that treat disease by orchestrating how genes in the body produce proteins involved in arthritis, ...
Jun 04, 2009 |
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Use the common cold virus to target and disrupt cancer cells?
A novel mechanism used by adenovirus to sidestep the cell's suicide program, could go a long way to explain how tumor suppressor genes are silenced in tumor cells and pave the way for a new type of targeted ...
Aug 25, 2010 |
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SIRT1 takes down tumors
Yuan et al. have identified another anti-cancer effect of the "longevity" protein SIRT1. By speeding the destruction of the tumor promoter c-Myc, SIRT1 curbs cell division. The study will be published online ...
Apr 13, 2009 |
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Researchers find a weak link in cancer cell armor
(PhysOrg.com) -- Professor Robert Weiss has found that when two particular genes are inhibited, cancer cells are destroyed at a greater rate. The study is published in the Nov. 9 issue of PNAS.
Nov 11, 2009 |
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Scientists show TAp63 suppresses cancer metastasis
Long overshadowed by p53, its famous tumor-suppressing sibling, the p63 gene does the tougher, important job of stifling the spread of cancer to other organs, researchers at The University of Texas MD Anderson Cancer Center ...
Oct 20, 2010 |
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P53
More reference expression data
p53 (also known as protein 53 or tumor protein 53), is a transcription factor which in humans is encoded by the TP53 gene. p53 is important in multicellular organisms, where it regulates the cell cycle and thus functions as a tumor suppressor that is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome," "the guardian angel gene," and the "master watchman," referring to its role in conserving stability by preventing genome mutation.
The name p53 is in reference to its apparent molecular mass: it runs as a 53 kilodalton (kDa) protein on SDS-PAGE. But based on calculations from its amino acid residues, p53's mass is actually only 43.7kDa. This difference is due to the high number of proline residues in the protein which slow its migration on SDS-PAGE, thus making it appear heavier than it actually is. This effect is observed with p53 from a variety of species, including humans, rodents, frogs, and fish.
For more information about P53, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
