News tagged with p53 tumor suppressor

Novel compound selectively kills cancer cells

A cancer cell may seem out of control, growing wildly and breaking all the rules of orderly cell life and death. But amid the seeming chaos there is a balance between a cancer cell's revved-up metabolism and skyrocketing ...

Jul 13, 2011
4.9 / 5 (9) 1 | with audio podcast

Toward new drugs that turn genes on and off

Scientists in Michigan and California are reporting an advance toward development of a new generation of drugs that treat disease by orchestrating how genes in the body produce proteins involved in arthritis, ...

Jun 04, 2009
5 / 5 (6) 0

SIRT1 takes down tumors

Yuan et al. have identified another anti-cancer effect of the "longevity" protein SIRT1. By speeding the destruction of the tumor promoter c-Myc, SIRT1 curbs cell division. The study will be published online ...

Apr 13, 2009
4.6 / 5 (5) 0

Potent metastasis inhibitor identified

Researchers at Children's Hospital Boston have isolated a potent inhibitor of tumor metastasis made by tumor cells, one that could potentially be harnessed as a cancer treatment. Their findings were published in the online ...

Jun 22, 2009
4.8 / 5 (4) 0

A chaperone for the 'guardian of the genome'

The protein p53 plays an essential role in the prevention of cancer by initiating the controlled death of a cell with damaged genes which is in danger to transform into a cancerous cell. The heat shock protein Hsp90, in turn, ...

Sep 07, 2011
5 / 5 (3) 0 | with audio podcast

Loss of 'guardian angel' gene prompts premature birth

Mutation of a gene that helps protect the body from genetic instability leads to cellular and molecular changes in the pregnant uterus that trigger premature birth, according to a study appearing online Feb. ...

Feb 01, 2010
5 / 5 (2) 0