News tagged with p53 tumor suppressor gene
Researchers identify potential molecular target to prevent growth of cancer cells
Researchers have shown for the first time that the protein fortilin promotes growth of cancer cells by binding to and rendering inert protein p53, a known tumor suppressor. This finding by researchers at the University of ...
Sep 16, 2011 |
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Novel compound selectively kills cancer cells
A cancer cell may seem out of control, growing wildly and breaking all the rules of orderly cell life and death. But amid the seeming chaos there is a balance between a cancer cell's revved-up metabolism and skyrocketing ...
Jul 13, 2011 |
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Researchers find link between DNA damage and immune response
Researchers offer the first evidence that DNA damage can lead to the regulation of inflammatory responses, the body's reaction to injury. The proteins involved in the regulation help protect the body from infection.
Mar 31, 2011 |
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Researchers find new role for cancer protein p53
The gene for the protein p53 is the most frequently mutated in human cancer. It encodes a tumor suppressor, and traditionally researchers have assumed that it acts primarily as a regulator of how genes are ...
Mar 02, 2011 |
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Cancer cell survival is not 'miR-ly' dependent on p53
Squamous cell carcinoma (SCC) is a common type of skin cancer. In this paper, Leif Ellisen and colleagues at Mass General Hospital investigated the p53-related proteins p63 and p73 in SCC cells, and discovered a feedback ...
Jan 10, 2011 |
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Small molecule may disarm enemy of cancer-fighting p53
A pioneering clinical trial is testing the effectiveness in leukemia of a small molecule that shuts down MDM2, a protein that can disable the well-known tumor suppressor p53.
Dec 07, 2010 |
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Scientists define molecular on-off switches for cancer and autoimmunity
A new report published in the October 2010 print issue of The FASEB Journal offers a ray of hope in the search for new cancer drugs. By examining the seemingly conflicting roles of how oncogenes and tumor suppressor genes ...
Sep 30, 2010 |
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Use the common cold virus to target and disrupt cancer cells?
A novel mechanism used by adenovirus to sidestep the cell's suicide program, could go a long way to explain how tumor suppressor genes are silenced in tumor cells and pave the way for a new type of targeted ...
Aug 25, 2010 |
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Cross Talk Between Oncogenes Suggests Treatment Combination in Esophageal Cancer
(PhysOrg.com) -- Using a three-dimensional tissue culture system that mimics esophageal tissue growth of the particularly aggressive type of tumors known as ESCC (esophageal squamous cell cancer), Penn researchers have discovered ...
Apr 20, 2010 |
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Why cancer drugs lose their power: Platinum-based cancer drugs destroy tumor cells by binding to DNA strands
(PhysOrg.com) -- For 30 years, the chemotherapy drug cisplatin has been one of doctors' first lines of defense against tumors, especially those of the lung, ovary and testes. While cisplatin is often effective ...
Apr 14, 2010 |
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Loss of 'guardian angel' gene prompts premature birth
Mutation of a gene that helps protect the body from genetic instability leads to cellular and molecular changes in the pregnant uterus that trigger premature birth, according to a study appearing online Feb. ...
Feb 01, 2010 |
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Segregating out UbcH10's role in tumor formation
A ubiquitin-conjugating enzyme that regulates the cell cycle promotes chromosome missegregation and tumor formation, according to van Ree et al. in the January 11 issue of the Journal of Cell Biology.
Jan 11, 2010 |
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Toward new drugs that turn genes on and off
Scientists in Michigan and California are reporting an advance toward development of a new generation of drugs that treat disease by orchestrating how genes in the body produce proteins involved in arthritis, ...
Jun 04, 2009 |
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Fat droplet nanoparticle delivers tumor suppressor gene to tumor and metastatic cells
Dr. Esther Chang describes the most recent developments in human trials of the first systemic, non-viral, tumor-targeted, nanoparticle method designed to restore normal gene function to tumor cells while completely bypassing ...
Nanotechnology / Bio & Medicine
Apr 20, 2009 |
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Chemopreventive isothiocyanates selectively depletes mutant p53 in tumor cells
Researchers at Lombardi Comprehensive Cancer Center at Georgetown University Medical Center have demonstrated that naturally-occurring compounds can selectively deplete mutant p53 and restore "wild type" function to p53 in ...
Apr 20, 2009 |
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