News tagged with p53 pathway
Targeted therapy reactivates 'guardian of the genome' in resistant cancer
A study demonstrating pharmacological rescue of a key tumor suppressor may lead to new therapeutic strategies for human cancer and significantly broaden the types of tumors that respond to targeted therapy, including those ...
Nov 15, 2010 |
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Advances reported in quest for drugs targeting childhood cancer
Investigators believe they have identified the founding member of a chemical family they hope will lead to a new class of cancer drugs, the first designed specifically against a childhood tumor, according ...
Mar 29, 2010 |
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Loss of 'guardian angel' gene prompts premature birth
Mutation of a gene that helps protect the body from genetic instability leads to cellular and molecular changes in the pregnant uterus that trigger premature birth, according to a study appearing online Feb. ...
Feb 01, 2010 |
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Tumor suppressor p53 prevents cancer progression in cells with missegregated chromosomes
Cells missegregate a chromosome approximately once every hundred divisions. But don't be too alarmed: new research in the Journal of Cell Biology shows that the tumor suppressor p53 limits the growth of cel ...
Feb 01, 2010 |
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Scientists identify natural anti-cancer defenses
Canadian researchers have discovered a novel molecular mechanism that prevents cancer. In the December 11 edition of the prestigious journal Molecular Cell, scientists from the Université de Montréal and th ...
Dec 11, 2009 |
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Antitumor activity of nutlin-3 in neuroblastoma with wild-type p53
The small-molecule inhibitor nutlin-3 may be a viable treatment option for neuroblastoma patients with wild-type p53 activity, according to a new study published online November 10 in the Journal of the National Cancer In ...
Nov 10, 2009 |
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Singapore scientists discover widely sought molecular key to understanding p53 tumor suppressor gene
Scientists at the Singapore Immunology Network (SIgN) have determined how the master gene regulator p53 could switch a gene in a cell "on" or "off" by recognizing specific sequences of nucleotides in the gene's DNA.
Oct 13, 2009 |
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New investigational treatment for bladder cancer
A team of researchers, led by Columbia University Medical Center faculty, has identified a new investigational therapy for the treatment of bladder cancer. The discovery was made using a new research model, using mice, which ...
Mar 12, 2009 |
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