News tagged with oncogenes
Jarid2 may break the Polycomb silence
Historically, fly and human Polycomb proteins were considered textbook exemplars of transcriptional repressors, or proteins that silence the process by which DNA gives rise to new proteins. Now, work by a ...
Apr 30, 2012 |
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Suppressing activity of common intestinal bacteria reduces tumor growth
A team of University of California, San Diego School of Medicine researchers has discovered that common intestinal bacteria appear to promote tumor growths in genetically susceptible mice, but that tumorigenesis can be suppressed ...
May 09, 2010 |
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Blocking an oncogene in liver cancer could be potential therapy option
Scientists have found that a synthetic molecule they designed can block activation of a gene in liver cancer cells, halting a process that allows some of those cancer cells to survive chemotherapy.
Oct 12, 2010 |
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New Hope for Deadly Childhood Bone Cancer
(PhysOrg.com) -- Researchers at Huntsman Cancer Institute (HCI) at the University of Utah have shed new light on Ewing’s sarcoma, an often deadly bone cancer that typically afflicts children and young adults. Their research ...
Aug 31, 2009 |
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Gene may be good target for tough-to-kill prostate cancer cells
Purdue University scientists believe they have found an effective target for killing late-stage, metastatic prostate cancer cells.
Sep 27, 2011 |
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New melanoma tumor suppressor gene uncovered
National Institutes of Health (NIH) researchers have identified a gene that suppresses tumor growth in melanoma, the deadliest form of skin cancer. The finding is reported today in the journal Nature Genetics as part of a s ...
Mar 29, 2009 |
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Scientists discover first breast cancer 'oncogene' in five years
(PhysOrg.com) -- Scientists have pinpointed a key cancer-causing gene that, when overactive, triggers a particularly aggressive type of breast cancer to develop.
Feb 18, 2011 |
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Worm studies shed light on human cancers
(PhysOrg.com) -- Research in the worm is shedding light on a protein associated with a number of different human cancers, and may point to a highly targeted way to treat them.
Apr 21, 2011 |
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Cancer: 'Primitive' gene discovered
To find the causes for cancer, biochemists and developmental biologists at the University of Innsbruck, Austria, retraced the function of an important human cancer gene 600 million years back in time. For ...
Feb 11, 2010 |
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Study unmasks a stem cell origin of skin cancer and the genetic roots of malignancy
A constellation of different stem cell populations within our skin help it to cope with normal wear and tear. By constantly proliferating, the stem cells allow skin to replenish itself, allowing each cell to be replaced by ...
Feb 03, 2011 |
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Certain cancer therapies' success depends on presence of immune cell: study
The immune system may play a critical role in ensuring the success of certain types of cancer therapies, according to a new study by researchers at the Stanford University School of Medicine. The research showed treatments ...
Oct 27, 2010 |
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Researchers make major breakthrough in melanoma research
In a breakthrough that could lead to new treatments for patients with malignant melanoma, researchers from Mount Sinai School of Medicine have discovered that a particular protein suppresses the progression of melanoma through ...
Dec 22, 2010 |
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Cancer-causing bacterium targets tumor-suppressor protein
Researchers have discovered a mechanism by which Helicobacter pylori, the only known cancer-causing bacterium, disables a tumor suppressor protein in host cells.
Aug 02, 2010 |
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Revealing cancers' weak spots: Researchers exploit genetic 'co-dependence' to kill treatment-resistant tumor cells
(PhysOrg.com) -- Cancer cells fueled by the mutant KRAS oncogene, which makes them notoriously difficult to treat, can be killed by blocking a more vulnerable genetic partner of KRAS, report scientists at ...
Oct 20, 2009 |
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Researchers find oncogene is important in pancreatic cancer growth, spread
(PhysOrg.com) -- Researchers at the Mayo Clinic campus in Florida have found that PKC-iota (PKCi), an oncogene important in colon and lung cancers, is over-produced in pancreatic cancer and is linked to poor patient survival. ...
Feb 23, 2010 |
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Oncogene
An oncogene is a gene that has the potential to cause cancer. In tumor cells, they are often mutated or expressed at high levels. An oncogene is a gene found in the chromosomes of tumor cells whose activation is associated with the initial and continuing conversion of normal cells into cancer cells.
Most normal cells undergo a programmed form of death (apoptosis). Activated oncogenes can cause those cells that ought to die to survive and proliferate instead. Most oncogenes require an additional step, such as mutations in another gene, or environmental factors, such as viral infection, to cause cancer. Since the 1970s, dozens of oncogenes have been identified in human cancer. Many cancer drugs target the proteins encoded by oncogenes.
For more information about Oncogene, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
