Related topics: cancer cells · breast cancer · tumor · cancer · tumor cells

New method to untangle 3D cancer genome

Northwestern Medicine scientists have invented a new method for resolving rearranged chromosomes and their 3D structures in cancer cells, which can reveal key gene regulators that lead to the development of tumors, published ...

Activating ALC1: With a little help from friends

Chromatin remodeling—the packaging and unpackaging of genomic DNA and its associated proteins—regulates a host of fundamental cellular processes including gene transcription, DNA repair, programmed cell death as well ...

Gene's function may give new target for cancer drugs

(Phys.org)—Purdue University scientists have determined that a gene long known to be involved in cancer cell formation and chemotherapy resistance is key to proper RNA creation, an understanding that could one day lead ...

Jarid2 may break the Polycomb silence

Historically, fly and human Polycomb proteins were considered textbook exemplars of transcriptional repressors, or proteins that silence the process by which DNA gives rise to new proteins. Now, work by a team of researchers ...

Worm studies shed light on human cancers

(PhysOrg.com) -- Research in the worm is shedding light on a protein associated with a number of different human cancers, and may point to a highly targeted way to treat them.

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Oncogene

An oncogene is a gene that, when mutated or expressed at high levels, helps turn a normal cell into a cancer cell.

Many cells normally undergo a programmed form of death (apoptosis). Activated oncogenes can cause those cells to survive and proliferate instead. Most oncogenes require an additional step, such as mutations in another gene, or environmental factors, such as viral infection, to cause cancer. Since the 1970s, dozens of oncogenes have been identified in human cancer. Many cancer drugs target those DNA sequences and their products.

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